Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NAC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | NAC |
| Key Genes/Proteins | TNF, ERK, JNK, P38 |
| Related Diseases | Glaucoma, ROS, NEURODEGENERATION, NEUROINFLAMMATION |
| Related Pathways | MAPK |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
NAC["NAC"]
NAC -->|"inhibits"| Ros["Ros"]
NAC -.protects against.-> Rotenone["Rotenone"]
NAC -->|"inhibits"| ROS["ROS"]
NAC -.protects against.-> Neurodegeneration["Neurodegeneration"]
NAC -->|"inhibits"| Peroxidation["Peroxidation"]
NAC -->|"inhibits"| p38_MAPK["p38/MAPK"]
NAC -->|"treats"| Glaucoma["Glaucoma"]
NAC -->|"inhibits"| disulfidptosis["disulfidptosis"]
AUTOPHAGY["AUTOPHAGY"] -->|"activates"| NAC
APOPTOSIS["APOPTOSIS"] -->|"activates"| NAC
FERROPTOSIS["FERROPTOSIS"] -->|"activates"| NAC
TNF["TNF"] -->|"activates"| NAC
ERK["ERK"] -->|"activates"| NAC
JNK["JNK"] -->|"activates"| NAC| Target | Relation | Type | Str |
|---|---|---|---|
| ROS | inhibits | process | 0.90 |
| disulfidptosis | inhibits | process | 0.70 |
| MAPK | inhibits | pathway | 0.70 |
| Glaucoma | treats | disease | 0.70 |
| ROS | associated_with | phenotype | 0.45 |
| TNF | associated_with | gene | 0.45 |
| NEURODEGENERATION | associated_with | phenotype | 0.45 |
| NEUROINFLAMMATION | associated_with | phenotype | 0.45 |
| P38 | associated_with | gene | 0.45 |
| NUCLEUS ACCUMBENS | associated_with | brain_region | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AUTOPHAGY | activates | process | 0.50 |
| APOPTOSIS | activates | process | 0.50 |
| FERROPTOSIS | activates | process | 0.50 |
| TNF | activates | gene | 0.50 |
| ERK | activates | gene | 0.50 |
| JNK | activates | gene | 0.50 |
| N-ACETYLCYSTEINE | associated_with | drug | 0.45 |
| APOPTOSIS | associated_with | phenotype | 0.45 |
| AUTOPHAGY | associated_with | phenotype | 0.45 |
| DEFEROXAMINE | associated_with | drug | 0.45 |
| FERROPTOSIS | associated_with | phenotype | 0.45 |
| ERK | associated_with | gene | 0.45 |
| JNK | associated_with | gene | 0.45 |
| HYPERTENSION | associated_with | disease | 0.45 |
| MAPK | associated_with | gene | 0.45 |
| MAPK PATHWAY | associated_with | pathway | 0.45 |
| GLIOSIS | associated_with | phenotype | 0.45 |
| GLAUCOMA | associated_with | disease | 0.45 |
| ANXIETY | associated_with | disease | 0.45 |
| ASTROCYTES | associated_with | cell_type | 0.45 |
| DEPRESSION | associated_with | disease | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.459
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||