concept

MAPK PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAPK PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

85Connections

1Hypotheses

0Analyses

43Outgoing

16Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	MAPK PATHWAY
Key Genes/Proteins	ERK, DRP1, PINK1
Related Diseases	SENESCENCE, NEURODEGENERATION, OBESITY, NEUROINFLAMMATION, INFLAMMATION
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    MAPK_PATHWAY["MAPK PATHWAY"]
    MAPK_PATHWAY -->|"causes"| Oncogene_Induced_Senescence["Oncogene-Induced Senescence"]
    MAPK_PATHWAY -->|"regulates"| Senescence_Associated_Secretor["Senescence-Associated Secretory Phenotype"]
    MAPK_PATHWAY -->|"causes"| Langerhans_Cell_Histiocytosis["Langerhans Cell Histiocytosis"]
    MAPK_PATHWAY -->|"promotes"| Langerhans_cell_histiocytosis["Langerhans cell histiocytosis"]
    MAPK_PATHWAY -->|"involved_in"| Vascular_Remodelling["Vascular Remodelling"]
    MAPK_PATHWAY -->|"drives"| histiocyte_clonal_expansion["histiocyte clonal expansion"]
    MAPK_PATHWAY -->|"regulates"| cell_growth["cell growth"]
    MAPK_PATHWAY -.biomarker for.-> pilocytic_astrocytoma["pilocytic astrocytoma"]
    RAS["RAS"] -->|"activates"| MAPK_PATHWAY
    KIAA1549__BRAF["KIAA1549::BRAF"] -->|"activates"| MAPK_PATHWAY
    Trametinib["Trametinib"] -->|"inhibits"| MAPK_PATHWAY
    BRAF["BRAF"] -->|"activates"| MAPK_PATHWAY
    NST_628["NST-628"] -->|"inhibits"| MAPK_PATHWAY
    RIPK2["RIPK2"] -->|"activates"| MAPK_PATHWAY
    IRS1["IRS1"] -->|"component_of"| MAPK_PATHWAY

Outgoing (54)

Target	Relation	Type	Str
ERK	phosphorylates	gene	0.70
DRP1	regulates	gene	0.65
DRP1	inhibits	gene	0.65
DRP1	causes	gene	0.65
SENESCENCE	causes	phenotype	0.65
SENESCENCE	activates	phenotype	0.65
NEURODEGENERATION	activates	phenotype	0.65
OBESITY	interacts_with	disease	0.65
PINK1	causes	gene	0.65
NEUROINFLAMMATION	inhibits	phenotype	0.65
OBESITY	associated_with	disease	0.50
NRF2	associated_with	gene	0.50
DEPRESSION	associated_with	disease	0.45
MICROGLIA	associated_with	cell_type	0.45
MAPK	associated_with	gene	0.45
EZH2	associated_with	gene	0.45
ALS	associated_with	disease	0.45
DRP1	associated_with	gene	0.45
PYROPTOSIS	associated_with	phenotype	0.45
SENESCENCE	associated_with	phenotype	0.45
GLIOMA	associated_with	disease	0.45
CANCER	associated_with	disease	0.45
ERK	associated_with	gene	0.45
PI3K	associated_with	gene	0.45
AKT	associated_with	gene	0.45
TNF	associated_with	gene	0.45
APOPTOSIS	associated_with	phenotype	0.45
BRAF	associated_with	gene	0.45
NAC	associated_with	drug	0.45
P38	associated_with	gene	0.45
LACTATE	associated_with	phenotype	0.45
MITOPHAGY	associated_with	phenotype	0.45
PINK1	associated_with	gene	0.45
HSPA1A	associated_with	gene	0.45
CCL2	associated_with	gene	0.45
MAPT	associated_with	gene	0.45
TAU	associated_with	protein	0.45
BACE1	associated_with	gene	0.45
HDAC6	associated_with	gene	0.45
JNK	associated_with	gene	0.45
NEURONS	associated_with	cell_type	0.45
NEURON	associated_with	cell_type	0.45
CYTOKINES	associated_with	phenotype	0.45

Incoming (31)

Source	Relation	Type	Str
MICROGLIA	inhibits	cell_type	0.65
INFLAMMATION	activates	phenotype	0.65
INFLAMMATION	inhibits	phenotype	0.65
INFLAMMATION	regulates	phenotype	0.65
NEUROINFLAMMATION	regulates	phenotype	0.65
TNF	regulates	gene	0.65
LACTATE	activates	phenotype	0.65
MICROGLIA	activates	cell_type	0.65
OXIDATIVE STRESS	associated_with	phenotype	0.50
NEUROINFLAMMATION	associated_with	phenotype	0.45
TUMOR GROWTH	associated_with	phenotype	0.45
INFLAMMATION	associated_with	phenotype	0.45
NEURODEGENERATION	associated_with	phenotype	0.45
HYPERTENSION	associated_with	disease	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.45
DIMETHYL FUMARATE	associated_with	drug	0.45

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
DLK MAPK Pathway Inhibition to Block Tau-Induced Neurotoxici	0.609	neurodegeneration	Should microtubule-stabilizing drugs be

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MAPK PATHWAY

Understanding Entity Pages

Wiki Pages (20)

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