Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PRION PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | PRION PROTEIN |
| Key Genes/Proteins | LRRK2, TH |
| Related Diseases | CYTOKINES, NEURODEGENERATION |
Knowledge base pages for this entity
graph TD
PRION_PROTEIN["PRION PROTEIN"]
PRION_PROTEIN -->|"expressed in"| Prion_Disease["Prion Disease"]
PRION_PROTEIN -->|"target for"| Aging["Aging"]
PRION_PROTEIN -->|"target for"| Als["Als"]
PRION_PROTEIN -->|"activates"| Ferroptosis["Ferroptosis"]
PRION_PROTEIN -->|"expressed in"| Alzheimer["Alzheimer"]
PRNP["PRNP"] -->|"target for"| PRION_PROTEIN
FERROPTOSIS["FERROPTOSIS"] -->|"activates"| PRION_PROTEIN
ALZHEIMER["ALZHEIMER"] -->|"expressed in"| PRION_PROTEIN
AMYLOID["AMYLOID"] -->|"regulates"| PRION_PROTEIN
APOE["APOE"] -->|"regulates"| PRION_PROTEIN
IFN["IFN"] -->|"regulates"| PRION_PROTEIN
TAU["TAU"] -->|"regulates"| PRION_PROTEIN| Target | Relation | Type | Str |
|---|---|---|---|
| CYTOKINES | activates | phenotype | 0.65 |
| NEURODEGENERATION | implicated_in | disease | 0.55 |
| TH | expressed_in | gene | 0.55 |
| NEURODEGENERATION | participates_in | disease | 0.55 |
| HYPOTHALAMUS | associated_with | brain_region | 0.45 |
| HIPPOCAMPUS | associated_with | brain_region | 0.45 |
| THALAMUS | associated_with | brain_region | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| LRRK2 | regulates | gene | 0.65 |
| LRRK2 | causes | gene | 0.65 |
| SUBSTANTIA NIGRA | associated_with | brain_region | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||