disease

Prion Disease

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Prion Disease: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

246Connections

0Hypotheses

1Analyses

25Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Impact if Solved	Would solving this gap fundamentally change treatment or prevention?
Tractability	Is this answerable with current technology?
Under-exploration	Are too few researchers working on this?
Data Availability	Do we have datasets, models, or tools available?
Associated Genes	AKT, NDUFA9, PI3K, SLC6A3, SNCA, TUBB, TUBB3, TUBB4B
KG Connections	157 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    Prion_Disease["Prion Disease"] -->|"associated"| Akt["Akt"]
    style Akt fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Prion_Disease["Prion Disease"] -->|"associated"| Cell_Cycle["Cell Cycle"]
    style Cell_Cycle fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Prion_Disease["Prion Disease"] -->|"associated"| Pi3K["Pi3K"]
    style Pi3K fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Prion_Disease["Prion Disease"] -->|"expressed in"| Amyloid["Amyloid"]
    style Amyloid fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    SOLUBLE_OLIGOMERS["SOLUBLE OLIGOMERS"] -->|"associated"| Prion_Disease["Prion Disease"]
    style SOLUBLE_OLIGOMERS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    AKT["AKT"] -->|"associated"| Prion_Disease["Prion Disease"]
    style AKT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    NDUFA9["NDUFA9"] -->|"associated"| Prion_Disease["Prion Disease"]
    style NDUFA9 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PI3K["PI3K"] -->|"associated"| Prion_Disease["Prion Disease"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    SLC6A3["SLC6A3"] -->|"associated"| Prion_Disease["Prion Disease"]
    style SLC6A3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Prion_Disease fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (49)

Target	Relation	Type	Str
Akt	associated_with	pathway	0.55
Cell Cycle	associated_with	pathway	0.55
Pi3K	associated_with	pathway	0.55
Amyloid	expressed_in	pathway	0.55
Cell Cycle	regulates	pathway	0.55
Amyloid	activates	pathway	0.55
Apoptosis	biomarker_for	pathway	0.55
Protein Aggregation	activates	pathway	0.55
Ubiquitin-Proteasome	regulates	pathway	0.55
Proteasome	regulates	pathway	0.55
Dopaminergic	regulates	cell_type	0.55
Microglia	contributes_to	cell_type	0.55
Neuron	associated_with	cell_type	0.55
Neuron	stabilizes	cell_type	0.55
Microglia	activates	cell_type	0.55
Stem Cell	activates	cell_type	0.55
Astrocyte	activates	cell_type	0.55
T Cell	activates	cell_type	0.55
Ubiquitin-Proteasome	degrades	pathway	0.55
Neuron	expressed_in	cell_type	0.55
Neuron	activates	cell_type	0.55
Mitophagy	associated_with	pathway	0.55
Mitochondrial Function	regulates	pathway	0.55
CEREBROSPINAL FLUID	associated_with	concept	0.50
Neuron	regulates	cell_type	0.50

Incoming (197)

Source	Relation	Type	Str
SOLUBLE OLIGOMERS	associated_with	protein	0.80
PINK1/Parkin Pathway	associated_with	pathway	0.80
AKT	associated_with	gene	0.65
NDUFA9	associated_with	gene	0.65
PI3K	associated_with	gene	0.65
SLC6A3	associated_with	gene	0.65
SNCA	associated_with	gene	0.65
TUBB	associated_with	gene	0.65
TUBB3	associated_with	gene	0.65
TUBB4B	associated_with	gene	0.65
CX3CR1	contributes_to	gene	0.65
TREM2	contributes_to	gene	0.65
PI3K	regulates	gene	0.65
AKT	regulates	gene	0.65
GENES	associated_with	gene	0.65
ALZHEIMER	associated_with	gene	0.65
PARKINSON'S DISEASE	regulates	gene	0.65
PARKINSON	regulates	gene	0.65
SYNAPSE	regulates	gene	0.65
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.65
HUNTINGTON	associated_with	gene	0.65
AMYOTROPHIC LATERAL SCLEROSIS	causes	gene	0.65
TREM2	activates	gene	0.65
MICROGLIA	activates	gene	0.65
GENES	activates	gene	0.65
ALZHEIMER	causes	gene	0.65
PARKINSON	causes	gene	0.65
DEMENTIA	causes	gene	0.65
INFLAMMATION	causes	gene	0.65
NEURODEGENERATION	activates	gene	0.65
NEUROINFLAMMATION	causes	gene	0.65
PROGRANULIN	activates	gene	0.65
CX3CR1	activates	gene	0.65
HUNTINGTON	causes	gene	0.65
AGING	activates	gene	0.65
AMYLOID	activates	gene	0.65
ALZHEIMER'S DISEASE	activates	gene	0.65
NEURODEGENERATIVE DISEASES	activates	gene	0.65
ALZHEIMER	expressed_in	gene	0.65
PARKINSON	expressed_in	gene	0.65
HUNTINGTON	expressed_in	gene	0.65
AND	associated_with	gene	0.65
AND	causes	gene	0.65
AND	expressed_in	gene	0.65
PRNP	associated_with	gene	0.65
PROTEIN MISFOLDING	activates	gene	0.65
APOPTOSIS	biomarker_for	gene	0.65
PER	biomarker_for	gene	0.65
NEURODEGENERATION	biomarker_for	gene	0.65
AND	interacts_with	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

neurodegeneration | 2026-04-14 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Prion Disease

Understanding Entity Pages

Wiki Pages (21)

Prion Disease Knowledge Gaps

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

NRF2 Oxidative Stress Pathway

GSK-3β in Neurodegeneration

Tau Spreading Mechanism

Prion vs Tau/Alpha-Synuclein Propagation: Mechanistic Comparison

Tau Strain Diversity and Conformational Templating in Tauopathies

prion-disease

Copper Dyshomeostasis in Neurodegeneration

PMN310 Anti-Amyloid for AD (NCT06750432)

Synucleinopathies

Protein Aggregation Comparison in Neurodegeneration

Nanobody Therapy for Neurodegenerative Diseases

Fatal Familial Insomnia

Experiment Prioritization Index — Neurodegeneration

NF-kB Signaling Pathway in Neurodegeneration

UBE2L3 — Ubiquitin-Conjugating Enzyme E2 L3

Variably Protease-Sensitive Prionopathy (VPSPr)

er-stress-neurodegeneration