Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Progressive Supranuclear Palsy: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| MAPT | interacts_with | gene | 0.65 |
| INFLAMMATION | regulates | phenotype | 0.65 |
| MAPT | associated_with | gene | 0.50 |
| AQP4 | associated_with | gene | 0.50 |
| APP | associated_with | gene | 0.50 |
| TH | associated_with | gene | 0.50 |
| HDAC3 | associated_with | gene | 0.50 |
| BRD4 | associated_with | gene | 0.50 |
| TDP-43 | associated_with | gene | 0.45 |
| TIDEGLUSIB | associated_with | drug | 0.45 |
| CORTEX | associated_with | brain_region | 0.45 |
| SPINAL CORD | associated_with | brain_region | 0.45 |
| TEMPORAL LOBE | associated_with | brain_region | 0.45 |
| LOCUS COERULEUS | associated_with | brain_region | 0.45 |
| CEREBELLUM | associated_with | brain_region | 0.45 |
| BASAL GANGLIA | associated_with | brain_region | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MAPT | biomarker_for | protein | 0.92 |
| 3R/4R Tau Ratio | associated_with | biomarker | 0.90 |
| Tau Aggregates | biomarker_for | biomarker | 0.85 |
| UFMylation Cascade | associated_with | pathway | 0.80 |
| Ufmylation Cascade | involved_in | pathway | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||