concept

DLB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DLB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

159Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

6Experiments

1Debates

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💡 Concept Info

Name	DLB
Key Genes/Proteins	AD, APOE, APP, ATG5, AΒ
Related Diseases	ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS
Linked Hypotheses	1 hypotheses

Wiki Pages (19)

Knowledge base pages for this entity

Canonical Page

Visual Hallucinations in Dementia With Lewy Bodies

mechanism · 2418 words

→

DLB, Parkinson's Disease, and Alzheimer's Disease: Cross-Disease Comparison Matrix

disease · 3237 words

→

Pathway Diagram

graph TD
    DLB[DLB]
    DLB ---|co-discussed| PARKINSON[PARKINSON]
    DLB ---|co-discussed| PARKINSON_S[PARKINSON'S]
    DLB ---|co-discussed| PREFRONTAL[PREFRONTAL]
    DLB ---|co-discussed| MICROGLIA[MICROGLIA]
    DLB ---|co-discussed| LOCUS_COERULEUS[LOCUS COERULEUS]
    DLB ---|co-discussed| TAU[TAU]
    MICROGLIA ---|associated| DLB
    ALZHEIMER[ALZHEIMER] ---|co-discussed| DLB
    ALZHEIMER_S[ALZHEIMER'S] ---|co-discussed| DLB
    DEMENTIA[DEMENTIA] ---|co-discussed| DLB
    CORTEX[CORTEX] ---|co-discussed| DLB
    ALS[ALS] ---|co-discussed| DLB

Outgoing (106)

Target	Relation	Type	Str
PROGRESSIVE SUPRANUCLEAR PALSY	interacts_with	disease	0.60
TAU	interacts_with	gene	0.60
TAU	regulates	gene	0.60
MICROGLIA	activates	cell_type	0.60
PARKINSON'S DISEASE	activates	disease	0.60
PD	activates	gene	0.60
NEUROINFLAMMATION	interacts_with	pathway	0.60
PD	co_discussed	gene	0.60
PARKINSON'S DISEASE	co_discussed	disease	0.60
LRP1	associated_with	gene	0.60
LRP1	expresses	gene	0.60
PD	expresses	gene	0.60
FTD	expresses	gene	0.60
PD	causes	gene	0.60
PINK1	activates	gene	0.60
LEWY BODY DEMENTIA	co_discussed	disease	0.60
STING	markers	gene	0.60
PARKINSON'S DISEASE	associated_with	disease	0.60
PD	associated_with	gene	0.60
GBA	expresses	gene	0.60
GBA	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
PARKINSON'S DISEASE	expresses	disease	0.60
PD	regulates	gene	0.60
PARKINSON'S DISEASE	causes	disease	0.60
TAU	expresses	gene	0.60
NEURON	causes	cell_type	0.60
PINK1	causes	gene	0.60
PINK1	expresses	gene	0.60
PROGRESSIVE SUPRANUCLEAR PALSY	co_discussed	disease	0.60
PD	disrupts	gene	0.60
INFLAMMASOME	activates	pathway	0.60
NLRP3	activates	gene	0.60
OXIDATIVE STRESS	activates	pathway	0.60
PROGRESSIVE SUPRANUCLEAR PALSY	regulates	disease	0.60
NEURON	expresses	cell_type	0.60
NEURONS	expresses	cell_type	0.60
NEURON	associated_with	cell_type	0.60
NEURONS	associated_with	cell_type	0.60
FRONTOTEMPORAL DEMENTIA	co_discussed	disease	0.60
FTD	regulates	gene	0.60
ULK1	regulates	gene	0.60
FRONTOTEMPORAL DEMENTIA	regulates	disease	0.60
FRONTOTEMPORAL DEMENTIA	disrupts	disease	0.60
FTD	disrupts	gene	0.60
PARKINSON DISEASE	disrupts	disease	0.60
PSEN1	interacts_with	gene	0.60
OLIGODENDROCYTES	co_discussed	cell_type	0.60
PARKINSON DISEASE	co_discussed	disease	0.60
FTD	causes	gene	0.60

Incoming (53)

Source	Relation	Type	Str
mechanisms-dlb-autonomic-dysfunction-pathway	describes	wiki	0.90
26655867	was greatest in	paper	0.90
SNCA	cross_disease_mechanism_in	gene_or_pathway	0.84
MICROGLIA	associated_with	cell_type	0.64
ALZHEIMER'S DISEASE	associated_with	disease	0.60
AD	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	disease	0.60
AD	co_discussed	gene	0.60
ALZHEIMER'S DISEASE	co_discussed	disease	0.60
AD	regulates	gene	0.60
AD	inhibits	gene	0.60
ATG5	regulates	gene	0.60
AD	markers	gene	0.60
AD	targets	gene	0.60
CHOLINERGIC	disrupts	cell_type	0.60
AD	causes	gene	0.60
ALZHEIMER'S DISEASE	causes	disease	0.60
CHOLINERGIC	associated_with	cell_type	0.60
AD	expresses	gene	0.60
AD	associated_with	gene	0.60
AΒ	associated_with	gene	0.60
AΒ	causes	gene	0.60
APP	expresses	gene	0.60
AΒ	expresses	gene	0.60
AD	disrupts	gene	0.60
ALZHEIMER'S DISEASE	regulates	disease	0.60
AΒ	interacts_with	gene	0.60
CORTICOBASAL DEGENERATION	co_discussed	disease	0.60
APOE	expresses	gene	0.60
APOE	associated_with	gene	0.60
DJ1	co_discussed	gene	0.60
APOE	causes	gene	0.60
CJD	co_discussed	gene	0.60
CREUTZFELDT-JAKOB	co_discussed	disease	0.60
CJD	associated_with	gene	0.60
AΒ	co_discussed	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	co_discussed	disease	0.60
ALZHEIMER'S	co_discussed	entity	0.50
DEMENTIA	co_discussed	entity	0.50
CORTEX	co_discussed	entity	0.50
AXON	co_discussed	entity	0.50
APOE	co_discussed	entity	0.50
CBD	co_discussed	entity	0.50
CERAMIDE	co_discussed	entity	0.50
ALZHEIMER	co_discussed	entity	0.50
CYTOKINE	co_discussed	entity	0.50
CHOLINERGIC	co_discussed	entity	0.50
ALS	co_discussed	entity	0.50
APP	co_discussed	entity	0.50
ATG5	co_discussed	entity	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SNCA conformer propagation across PD, DLB, and MSA	0.820	multi	Cross-disease neurodegeneration mechanis

Mentioning Analyses (1)

Scientific analyses that reference this entity

Cross-disease neurodegeneration mechanism synthesis

neurodegeneration | 2026-04-28 | 17 hypotheses Top: 0.828

Experiments (6)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Tau Co-Pathology in DLB Clinical Heterogeneity	clinical	Neurodegeneration	0.400	0.50	human	proposed	$5,460,000
DLB Treatment Response Biomarkers — Predicting Cholinesterase Inhibito	clinical	Neurodegeneration	0.400	0.50	human	proposed	$6,550,000
Alpha-Synuclein Staging and Spreading in DLB — Spatial Propagation Map	validation	Parkinson's Disease	0.400	0.50	cell_line	proposed	$160,000
DLB Cognitive Fluctuation Mechanism Experiment	clinical	Neurodegeneration	0.400	0.50	human	proposed	$6,550,000
Cholinergic System Dysfunction in DLB — Mechanisms and Therapeutic Res	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Genetic Risk Modifiers in DLB Phenotype	clinical	Neurodegeneration	0.400	0.50	human	proposed	$7,500,000

Related Papers (3)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple sys [PMID:9682846]	Unknown	Neuroscience letters	1998
Mutation in the alpha-synuclein gene identified in families with Parkinson's dis [PMID:9197268]	Unknown	Science (New York, N.Y.)	1997
Alpha-synuclein in Lewy bodies. [PMID:9278044]	Unknown	Nature	1997

Debates (1)

Multi-agent debates referencing this entity

Which AD, PD, ALS, and FTD mechanisms recur across disease boundaries and yield

closed · Rounds: 4 · Score: 0.72 · 2026-04-28

Related Research

Hypotheses and analyses mentioning DLB in their description or question text

No additional research found

DLB

Understanding Entity Pages

Wiki Pages (19)

Visual Hallucinations in Dementia With Lewy Bodies

DLB, Parkinson's Disease, and Alzheimer's Disease: Cross-Disease Comparison Matrix

Dementia with Lewy Bodies (DLB)

DLB Cognitive Fluctuation Mechanism Experiment

DLB, PDD, and Alzheimer's Disease: Cross-Disease Comparison Matrix

Cholinergic System Dysfunction in DLB — Mechanisms and Therapeutic Restoration

DLB Knowledge Gaps

DLB-PD-AD Cross-Disease Comparison

DLB-PD-AD Comparison Matrix

Alpha-Synuclein Staging and Spreading in DLB — Spatial Propagation Mapping

DLB Cognitive Fluctuation Mechanisms

DLB Autonomic Dysfunction Pathway

DLB Cholinergic Dysfunction Mechanisms

DLB Cure Roadmap

DLB Treatment Response Biomarkers — Predicting Cholinesterase Inhibitor Response

Validated Hypothesis: SNCA conformer propagation across PD, DLB, and MSA

Alpha-Synuclein Prion-Like Propagation in DLB

Genetic Risk Modifiers in DLB Phenotype

Tau Co-Pathology in DLB Clinical Heterogeneity