Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Ric: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Oxidative Stress | associated_with | process | 0.95 |
| Inflammation | associated_with | process | 0.95 |
| NFE2L2 | upregulates | protein | 0.92 |
| HO1 | upregulates | protein | 0.92 |
| KEAP1 | downregulates | protein | 0.90 |
| NLRP3 | downregulates | protein | 0.90 |
| IL1B | downregulates | protein | 0.90 |
| IL6 | downregulates | protein | 0.90 |
| TNF | downregulates | protein | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.675
neuroinflammation | 2026-04-15 | 2 hypotheses Top: 0.605
neurodegeneration | 2026-04-14 | 0 hypotheses
neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.552
structural biology | 2026-04-12 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020] | Chua JP, De Calbiac H, Kabashi E, Barmad | Autophagy | 2022 | 2 |
| TDP-43 Pathology in Alzheimer's Disease. [PMID:34930382] | Meneses A, Koga S, O'Leary J, Dickson DW | Mol Neurodegener | 2021 | 2 |
| Protein transmission in neurodegenerative disease. [PMID:32203399] | Peng C, Trojanowski JQ, Lee VM | Nat Rev Neurol | 2020 | 2 |
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 2 |
| Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of [PMID:30335591] | Rusmini P, Cortese K, Crippa V, Cristofa | Autophagy | 2019 | 2 |
| Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic [PMID:40848726] | Zhao S, Li R, Xia Y, Wang X, Liu Z, Chu | Cell Stem Cell | 2025 | 1 |
| Dolutegravir induces endoplasmic reticulum stress at the blood-brain barrier. [PMID:39985305] | Huang C, Qu QR, Hoque MT, Bendayan R | FASEB J | 2025 | 1 |
| Profiling Tight Junction Protein Expression in Brain Vascular Malformations. [PMID:40429705] | Pedrosa L, Mosteiro A, Reyes L, Amaro S, | Int J Mol Sci | 2025 | 1 |
| Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegenerat [PMID:37995685] | Litvinchuk A, Suh JH, Guo JL, Lin K, Dav | Neuron | 2024 | 1 |
| The cell biology of APOE in the brain. [PMID:37805344] | Windham IA, Cohen S | Trends Cell Biol | 2024 | 1 |
| Neurovascular unit, neuroinflammation and neurodegeneration markers in brain dis [PMID:39526043] | Kempuraj D, Dourvetakis KD, Cohen J, Val | Front Cell Neurosci | 2024 | 1 |
| Vinpocetine prevents rotenone-induced Parkinson disease motor and non-motor symp [PMID:36965781] | ["Ishola IO", "Awogbindin IO", "Olubodun | Neurotoxicology | 2023 | 1 |
| The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegene [PMID:37957317] | Maxine R Nelson, Peng Liu, Ayushi Agrawa | Nature neuroscience | 2023 | 1 |
| The Genetics of Primary Familial Brain Calcification: A Literature Review. [PMID:37446066] | Chen SY, Ho CJ, Lu YT, Lin CH, Lan MY, T | Int J Mol Sci | 2023 | 1 |
| N protein of PEDV plays chess game with host proteins by selective autophagy. [PMID:36861818] | Zhai X, Kong N, Zhang Y, Song Y, Qin W, | Autophagy | 2023 | 1 |
| PIKFYVE inhibition mitigates disease in models of diverse forms of ALS. [PMID:36754049] | Hung ST, Linares GR, Chang WH, Eoh Y, Kr | Cell | 2023 | 1 |
| Fractalkine Enhances Hematoma Resolution and Improves Neurological Function via [PMID:37465997] | Chen X, He X, Xu F, Xu N, Sharifi NH, Zh | Stroke | 2023 | 1 |
| Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmon [PMID:35257044] | Calvier L, Herz J, Hansmann G | JACC Basic Transl Sci | 2022 | 1 |
| Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214] | Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia | J Inflamm Res | 2022 | 1 |
| CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases. [PMID:34492237] | Subbarayan MS, Joly-Amado A, Bickford PC | Pharmacol Ther | 2022 | 1 |