| Gene Symbol | LRRK2 |
| Full Name | LRRK2 (Leucine-Rich Repeat Kinase 2) |
| Chromosome | 12q12 |
| Protein Type | Protein |
| Amino Acids | 2527 aa |
| Pathways | MAPK |
| UniProt ID | Search UniProt |
| GeneCards | LRRK2 |
| Human Protein Atlas | LRRK2 |
| ARM (Armadillo) repeats | Protein-protein interaction domain at N-terminus |
| ANK (Ankyrin) repeats | Additional scaffolding domain |
| LRR (Leucine-Rich Repeat) | Regulatory domain |
| ROC (Ras of Complex) | GTPase domain that binds and hydrolyzes GTP |
| COR (C-terminal of ROC) | Dimerization domain |
| Kinase domain | Serine/threonine kinase catalytic core |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis |
| Known Drugs/Compounds | BIIB094, BIIB122, Cigarette Smoking, DNL201, Environmental Toxicants, levodopa |
| Interactions | 6-OHDA, ACETYLCHOLINE, ACHE, Actin, AD, AKT |
| SciDEX Hypotheses | LRRK2 G2019S Kinase Inhibition for Parkinson's Dis G2019S primarily raises baseline LRRK2 kinase acti Therapeutic Window Exists Because Amplified Signal (+6 more) |
| KG Connections | 2622 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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