gene 2,834 words KG: LRRK2 2026-03-24
kind:genesection:genesstate:publishedevidence:strong
Contents

LRRK2 — Leucine Rich Repeat Kinase 2

🧬 Gene Info
Gene SymbolLRRK2
Full NameLeucine Rich Repeat Kinase 2
Chromosome12q12
Protein TypeProtein
Primary ExpressionStriatum, Cerebral cortex, Kidney, Lungs
Amino Acids2527 aa
PathwaysMAPK
UniProt IDSearch UniProt
NCBI Gene ID120892
Ensembl IDENSG00000188906
OMIM609007
GeneCardsLRRK2
Human Protein AtlasLRRK2
Associated DiseasesALS, Aging, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/CompoundsRAPAMYCIN, levodopa, Cigarette Smoking, BIIB094, VALPROIC ACID, rapamycin
InteractionsATG16L1, RB1CC1, GABARAP, ERN1, STAT3, IFNG
KG Connections2480 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
APOE-Dependent Autophagy Restoration
Score: 0.61
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59

Related Analyses (15)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (23)

AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40
Computational Modeling of Alpha-Synuclein Propagation in PD
validation · proposed · Score: 0.40
Alpha-Synuclein Spreading Mechanism — Prion-Like Propagation
exploratory · proposed · Score: 0.40
Combination Therapy Sequencing in Parkinson's Disease
validation · proposed · Score: 0.40
DNA Damage Repair Deficiency Validation Study in Parkinson's
clinical · proposed · Score: 0.40

See Also (5)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: causes
AKT1 Gene
gene · KG edge: activates
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: associated_with
acetylcholine
general · KG edge: co_discussed
ABCA7 (Redirect)
redirect · KG edge: associated_with

Knowledge Graph (12 edges)

LRRK2 co_discussed MLKL
LRRK2 co_discussed STING
LRRK2 phosphorylates MAP1LC3A
LRRK2 phosphorylates MAPK14
LRRK2 phosphorylates MAVS
LRRK2 phosphorylates MLKL
LRRK2 phosphorylates MLST8
LRRK2 phosphorylates MTOR
LRRK2 phosphorylates NBR1
LRRK2 phosphorylates OPTINEURIN