gene

TREH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TREH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

181Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

Summary

Trehalase - a glycogen hydrolase enzyme involved in trehalose metabolism, autophagy induction, and implicated in Alzheimer's disease, diabetes, and cellular stress resistance

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🧬 Gene Info

Gene Symbol	TREH
Full Name	Trehalase
Chromosome	11q23.3
Function	is a non-reducing disaccharide found in many organisms, where it serves as a protectant against various environmental stresses.
Primary Expression	the small intestine, kidney, liver, and brain
Subcellular Localization	the cytosol
Molecular Weight	65 kDa
Amino Acids	583 aa
Pathways	Autophagy, Chaperone, Tdp-43, autophagy pathway, oxidative stress response
UniProt ID	[Q9NUH0](https://www.uniprot.org/uniprot/Q9NUH0)
Ensembl ID	ENSG00000143537
GeneCards	TREH
Human Protein Atlas	TREH
Molecular weight	~65 kDa (membrane form)
Catalytic domain	GH37 signature motifs
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Ataxia, Huntington, Neuroblastoma, Parkinson
Known Drugs/Compounds	rapamycin
Interactions	ATG10, ATG12, TFEB, CALCINEURIN, HSPB8, CTSB
KG Connections	181 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TREH["TREH"]
    TREH -->|"activates"| Neurodegeneration["Neurodegeneration"]
    TREH -->|"activates"| ATG10["ATG10"]
    TREH -->|"activates"| Autophagy["Autophagy"]
    TREH -->|"activates"| NEURODEGENERATION["NEURODEGENERATION"]
    TREH -->|"activates"| ATG12["ATG12"]
    TREH -->|"activates"| TFEB["TFEB"]
    TREH -->|"activates"| CALCINEURIN["CALCINEURIN"]
    TREH -->|"activates"| GENES["GENES"]
    TREH -->|"activates"| AUTOPHAGY["AUTOPHAGY"]
    TREH -->|"expressed in"| Spinal_Cord["Spinal Cord"]
    CALCINEURIN -->|"activates"| TREH
    ATG12 -->|"activates"| TREH
    TFEB -->|"activates"| TREH
    GENES -->|"activates"| TREH
    ATG10 -->|"activates"| TREH
    TREHALOSE["TREHALOSE"] -->|"activates"| TREH

Outgoing (103)

Target	Relation	Type	Str
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Ataxia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Huntington	associated_with	disease	0.65
Neuroblastoma	associated_with	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
BECN1	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
PPP3CB	associated_with	gene	0.60
HSPB8	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
BAG3	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
ATG10	activates	gene	0.60
LAMP1	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
MCOLN1	associated_with	gene	0.60
STUB1	associated_with	gene	0.60
STIP1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
GLA	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
LGALS3	associated_with	gene	0.60
ATG12	activates	gene	0.60
TFEB	activates	gene	0.60
PPARGC1A	associated_with	gene	0.60
CALCINEURIN	activates	gene	0.60
BCL2	associated_with	gene	0.60
TPP1	associated_with	gene	0.60
P62	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
TDP-43	associated_with	gene	0.60
Neural Progenitor	associated_with	cell_type	0.60
neurodegeneration	activates	disease	0.60
cerebellum	expressed_in	brain_region	0.60
XPO1	associated_with	gene	0.60
Mtor	associated_with	pathway	0.60
Autophagy	activates	pathway	0.60
DNA	associated_with	gene	0.60
Chaperone	associated_with	pathway	0.60
PARKINSON	associated_with	gene	0.60
ATG	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
ALS	associated_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
HUNTINGTON	associated_with	gene	0.60

Incoming (78)

Source	Relation	Type	Str
BAG3	activates	entity	0.60
BCL2	activates	entity	0.60
BECN1	activates	entity	0.60
CTSB	activates	entity	0.60
GAPDH	activates	entity	0.60
GLA	activates	entity	0.60
HSPA8	activates	entity	0.60
HSPB8	activates	entity	0.60
LAMP1	activates	entity	0.60
LAMP2A	activates	entity	0.60
LGALS3	activates	entity	0.60
MAP1LC3B	activates	entity	0.60
MCOLN1	activates	entity	0.60
MTOR	activates	entity	0.60
P62	activates	entity	0.60
PPARGC1A	activates	entity	0.60
PPP3CB	activates	entity	0.60
SOD1	activates	entity	0.60
SQSTM1	activates	entity	0.60
STIP1	activates	entity	0.60
STUB1	activates	entity	0.60
TARDBP	activates	entity	0.60
TPP1	activates	entity	0.60
ALS	activates	entity	0.60
STIP1	associated_with	gene	0.60
LGALS3	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
MCOLN1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
TPP1	associated_with	gene	0.60
GLA	associated_with	gene	0.60
CALCINEURIN	activates	gene	0.60
ATG12	activates	gene	0.60
STUB1	associated_with	gene	0.60
PPARGC1A	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
PPP3CB	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
TFEB	activates	gene	0.60
MTOR	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
HSPB8	associated_with	gene	0.60
P62	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
BAG3	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Why do structurally diverse sugars (trehalose, melibiose, lactulose) produce ide

neurodegeneration | 2026-04-08 | 0 hypotheses

What determines the specificity of calcium-dependent PPP3/calcineurin activation

neurodegeneration | 2026-04-07 | 0 hypotheses

How does controlled lysosomal membrane permeabilization induce autophagy without

neurodegeneration | 2026-04-07 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found