Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SHANK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SHANK2 |
| Chromosome | 11q13.2 |
| Protein Type | Scaffold Protein |
| Function | The SHANK2 gene encodes a scaffold protein involved in various neurological processes: |
| Primary Expression | dendritic spines where it organizes the postsynaptic machinery, regulating synaptic transmission and plasticity |
| Subcellular Localization | s. The genomic organization includes a proline-rich region, ankyrin repeat domains, SH3 domain, and PDZ domains, each me |
| Amino Acids | 630 aa |
| Pathways | Apoptosis |
| UniProt ID | Q9UQB8 |
| NCBI Gene ID | 22941 |
| Ensembl ID | ENSG00000141013 |
| GeneCards | SHANK2 |
| Human Protein Atlas | SHANK2 |
| Attribute | Value |
| Gene Name | SH3 and Multiple Ankyrin Repeat Domains 2 |
| Associated Diseases | neurodegeneration |
| KG Connections | 27 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SHANK2["SHANK2"]
SHANK2 -->|"target for"| Ischemia["Ischemia"]
SHANK2 -->|"target for"| Stroke["Stroke"]
SHANK2 -->|"target for"| Als["Als"]
SHANK2 -->|"expressed in"| SYN1["SYN1"]
SHANK2 -->|"target for"| APOPTOSIS["APOPTOSIS"]
SHANK2 -->|"expressed in"| PRKACB["PRKACB"]
SHANK2 -->|"expressed in"| PSD95["PSD95"]
SHANK2 -->|"expressed in"| Synaptic_Plasticity["Synaptic Plasticity"]
SYT1["SYT1"] -->|"expressed in"| SHANK2
STROKE["STROKE"] -->|"target for"| SHANK2
BCL_2["BCL-2"] -->|"expressed in"| SHANK2
BDNF["BDNF"] -->|"expressed in"| SHANK2| Target | Relation | Type | Str |
|---|---|---|---|
| Ischemia | therapeutic_target | disease | 0.65 |
| Stroke | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Stroke | activates | disease | 0.65 |
| Ischemia | activates | disease | 0.65 |
| SYN1 | expressed_in | gene | 0.60 |
| PRKACB | expressed_in | gene | 0.60 |
| PSD95 | expressed_in | gene | 0.60 |
| CREB1 | expressed_in | gene | 0.60 |
| SYT1 | expressed_in | gene | 0.60 |
| APOPTOSIS | therapeutic_target | gene | 0.60 |
| Synaptic Plasticity | expressed_in | pathway | 0.60 |
| Apoptosis | therapeutic_target | pathway | 0.60 |
| Neuron | therapeutic_target | cell_type | 0.60 |
| Bdnf | expressed_in | protein | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| SHANK3 | regulates | gene | 0.55 |
| Cortex | expressed_in | brain_region | 0.55 |
| Hippocampus | expressed_in | brain_region | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||