concept

SODIUM BUTYRATE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SODIUM BUTYRATE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

50Connections

0Hypotheses

1Analyses

40Outgoing

10Incoming

0Experiments

1Debates

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💡 Concept Info

Name	SODIUM BUTYRATE
Key Genes/Proteins	AKT, CGAS, IL10, IL6, MYD88
Related Diseases	APOPTOSIS, AUTOPHAGY, FERROPTOSIS, INFLAMMATION, MITOPHAGY
Related Pathways	GLP-1 signaling

Pathway Diagram

graph TD
    SODIUM_BUTYRATE[SODIUM BUTYRATE]
    SODIUM_BUTYRATE -->|activates| AMPK[AMPK]
    SODIUM_BUTYRATE -->|treats| Intestinal_Epithelium_Barrier_[Intestinal Epithelium Barrier Injury]
    SODIUM_BUTYRATE -->|inhibits| INFLAMMATION[INFLAMMATION]
    SODIUM_BUTYRATE -->|inhibits| MICROGLIA[MICROGLIA]
    SODIUM_BUTYRATE -->|treats| SPINAL_CORD[SPINAL CORD]
    SODIUM_BUTYRATE -->|activates| APOPTOSIS[APOPTOSIS]
    SODIUM_BUTYRATE -->|regulates| PI3K_AKT_PATHWAY[PI3K/AKT PATHWAY]
    SODIUM_BUTYRATE -->|treats| MITOPHAGY[MITOPHAGY]

Outgoing (40)

Target	Relation	Type	Str
Oxidative Stress	associated_with	process	0.95
AMPK	activates	protein	0.92
Intestinal Epithelium Barrier Injury	treats	phenotype	0.89
GLP-1 signaling	enhances	pathway	0.70
AUTOPHAGY	activates	phenotype	0.65
MICROGLIA	activates	cell_type	0.65
SPINAL CORD	treats	brain_region	0.65
INFLAMMATION	inhibits	phenotype	0.65
MICROGLIA	inhibits	cell_type	0.65
MICROGLIA	regulates	cell_type	0.65
APOPTOSIS	activates	phenotype	0.65
PI3K/AKT PATHWAY	regulates	pathway	0.65
MITOPHAGY	treats	phenotype	0.65
MITOPHAGY	inhibits	phenotype	0.65
MITOPHAGY	activates	phenotype	0.65
SPINAL CORD	associated_with	brain_region	0.45
PYROPTOSIS	associated_with	phenotype	0.45
MITOPHAGY	associated_with	phenotype	0.45
FERROPTOSIS	associated_with	phenotype	0.45
APOPTOSIS	associated_with	phenotype	0.45
MICROGLIA	associated_with	cell_type	0.45
NEURONS	associated_with	cell_type	0.45
STROKE	associated_with	disease	0.45
CORTEX	associated_with	brain_region	0.45
INFLAMMATION	associated_with	phenotype	0.45
MYD88	associated_with	gene	0.45
TLR4	associated_with	gene	0.45
NLRP3	associated_with	gene	0.45
PI3K	associated_with	gene	0.45
AKT	associated_with	gene	0.45
RELA	associated_with	gene	0.45
STAT3	associated_with	gene	0.45
IL10	associated_with	gene	0.45
TNF	associated_with	gene	0.45
IL6	associated_with	gene	0.45
NRF2	associated_with	gene	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
STING	associated_with	gene	0.45
AUTOPHAGY	associated_with	phenotype	0.45
CGAS	associated_with	gene	0.45

Incoming (10)

Source	Relation	Type	Str
36761177	ameliorated	paper	0.90
36761177	protected against	paper	0.90
36761177	prevented	paper	0.90
36761177	remodeled	paper	0.90
36761177	regulated	paper	0.90
36761177	restored	paper	0.90
NEUROINFLAMMATION	associated_with	phenotype	0.45
PI3K/AKT PATHWAY	associated_with	pathway	0.45
SPINOCEREBELLAR ATAXIA	associated_with	disease	0.45
PROTEIN AGGREGATION	associated_with	phenotype	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Do physiological concentrations of SCFAs (μM range) achieve therapeutic effects

neurodegeneration | 2026-04-24 | 6 hypotheses Top: 0.670

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Do physiological concentrations of SCFAs (μM range) achieve therapeutic effects

closed · Rounds: 4 · Score: 0.63 · 2026-04-24

Related Research

Hypotheses and analyses mentioning SODIUM BUTYRATE in their description or question text

No additional research found