Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about STRESS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Name | STRESS |
| Summary | Page for Bed Nucleus of Stria Terminalis in Stress |
| Key Genes/Proteins | CRH, BDNF |
| Related Diseases | DEPRESSION, major depressive disorder |
| Linked Hypotheses | 11 hypotheses |
Knowledge base pages for this entity
graph TD
STRESS["STRESS"]
STRESS -->|"causes"| Anxiety["Anxiety"]
STRESS -->|"causes"| Cardiovascular_Disease["Cardiovascular Disease"]
STRESS -->|"triggers"| senescence["senescence"]
STRESS -->|"activates"| TDP_43["TDP-43"]
STRESS -->|"upregulates"| CRH["CRH"]
STRESS -->|"upregulates"| FKBP5["FKBP5"]
STRESS -->|"downregulates"| BDNF["BDNF"]
STRESS -->|"downregulates"| IL18["IL18"]
STMN2["STMN2"] -->|"downregulates"| STRESS
locus_coeruleus["locus coeruleus"] -->|"regulates"| STRESS| Target | Relation | Type | Str |
|---|---|---|---|
| DEPRESSION | causes | disease | 0.90 |
| epigenetic changes | induces | process | 0.90 |
| CRH | activates | protein | 0.72 |
| major depressive disorder | implicated_in | disease | 0.70 |
| BDNF | inhibits | protein | 0.64 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Paro Robotic Pet | associated_with | entity | 0.90 |
| STMN2 | downregulates | protein | 0.88 |
| locus coeruleus | regulates | brain_region | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Multi-Modal Stress Response Harmonization | 0.601 | neurodegeneration | Digital biomarkers and AI-driven early d |
| ER Stress Reduction as Adjunctive Therapy to Support Autopha | 0.566 | neurodegeneration | Why does iron chelation therapy worsen o |
| ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive | 0.512 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| Stress Granule Phase Separation Modulators | 0.490 | neurodegeneration | RNA binding protein dysregulation across |
| Neuronal Integrated Stress Response Modulation | 0.452 | neurodegeneration | Cell type vulnerability in Alzheimer's D |
| Nucleolar Stress Response Normalization | 0.378 | neurodegeneration | RNA binding protein dysregulation across |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.497
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.610
neurodegeneration | 2026-04-12 | 0 hypotheses
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-11 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3B [PMID:36692217] | Yang C, Wang Z, Kang Y, Yi Q, Wang T, Ba | Autophagy | 2023 | 3 |
| G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Gran [PMID:32302571] | Yang P, Mathieu C, Kolaitis RM, Zhang P, | Cell | 2020 | 3 |
| LINC00599 Promotes Pulmonary Hypertension via Liquid-Liquid Phase Separation Wit [PMID:40693377] | Wang Y, Yin L, Zheng S, Liu A, Liu C, Ba | Hypertension | 2025 | 1 |
| The important role of stress granules in prostate cancer development, progressio [PMID:40972860] | Xu Z, You H, Gu J, Jiang J, Yan Z, Jin X | Gene | 2025 | 1 |
| NPM1 inhibits tumoral antigen presentation to promote immune evasion and tumor p [PMID:39402629] | Wang X, Chai Y, Quan Y, Wang J, Song J, | J Hematol Oncol | 2024 | 1 |
| Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specifi [PMID:34739333] | Gwon Y, Maxwell BA, Kolaitis RM, Zhang P | Science | 2021 | 1 |
| Significance of NPM1 Gene Mutations in AML. [PMID:34576201] | Hindley A, Catherwood MA, McMullin MF, M | Int J Mol Sci | 2021 | 1 |
| NPM1-mutated acute myeloid leukemia: from bench to bedside. [PMID:32609823] | Falini B, Brunetti L, Sportoletti P, Mar | Blood | 2020 | 1 |
| Methylation of HPA axis related genes in men with hypersexual disorder. [PMID:28319850] | Jokinen J, Boström AE, Chatzittofis A, C | Psychoneuroendocrinology | 2017 | 1 |
| Insights into the regulation of neuronal viability by nucleophosmin/B23. [PMID:25908633] | Pfister JA, D'Mello SR | Exp Biol Med (Maywood) | 2015 | 1 |
| Development of alopecia areata is associated with higher central and peripheral [PMID:19020552] | Zhang X, Yu M, Yu W, Weinberg J, Shapiro | J Invest Dermatol | 2009 | 1 |
| Functions of the histone chaperone nucleolin in diseases. [PMID:17484127] | Storck S, Shukla M, Dimitrov S, Bouvet P | Subcell Biochem | 2007 | 1 |
| Cytokine associated neuroinflammation in Parkinson's disease: Molecular pathways [PMID:41512596] | ["Dhapola R", "Kumari S", "Sharma P", "P | Cytokine & growth factor revie | 2026 | 0 |
| STING is the scaffold protein for stress granule pre-condensation at the ER. [PMID:41917183] | Eom E, Kim J, Kim J, Kang SJ | Cell death and differentiation | 2026 | 0 |
| Stress granules: Guardians of cellular health and triggers of disease. [PMID:39995077] | ["Desai M", "Gulati K", "Agrawal M", "Gh | Neural regeneration research | 2026 | 0 |
| WFDC21P is essential for G3BP1-mediated RIG-I activation and antitumor immunity [PMID:41915747] | Li Z, Wang Y, Chen Z, Liu R, Lai ZH, Li | Proceedings of the National Ac | 2026 | 0 |
| NUP93 facilitates the nuclear import of SOX2 to activate G3BP1 transcription and [PMID:41896201] | Sun H, Yang C, Du J, Xu C, Chen Y, Chen | Cell death & disease | 2026 | 0 |
| Implications of virus-induced stress granules in tauopathies. [PMID:41673769] | Sharma S, Vandenakker A, Cortés-Pérez C, | Translational neurodegeneratio | 2026 | 0 |
| Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by sup [PMID:41920932] | Mulloy RP, Evseev D, Sharlin N, Bui-Mari | PLoS biology | 2026 | 0 |
| Stress granules at the crossroads of retroviral replication and antiviral immuni [PMID:41931190] | Akbarin MM, Farjami Z, Álvarez HR | Mol Biol Rep | 2026 | 0 |