Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TRIM24: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TRIM24 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, inhibits. Associated with Aging, Als, Alzheimer. Connected to 47 entities in the SciDEX knowledge graph.
| Gene Symbol | TRIM24 |
| Full Name | Tripartite Motif Containing 24 |
| Chromosome | 7q33 |
| Protein Type | Ligase |
| Function | is a transcriptional coactivator and E3 ubiquitin ligase that plays key roles in gene regulation, DNA damage response, and cellular stress responses [1](https://pubmed. |
| Primary Expression | various cancers: |
| Amino Acids | 008 aa |
| Exons | 17 |
| UniProt ID | [Q9Y2X9](https://www.uniprot.org/uniprot/Q9Y2X9) |
| Ensembl ID | ENSG00000108344 |
| OMIM | 603546 |
| GeneCards | TRIM24 |
| Human Protein Atlas | TRIM24 |
| RING finger | A C3HC4 RING domain with E3 ubiquitin ligase activity |
| B boxes | Two B-box domains involved in protein-protein interactions |
| Associated Diseases | Aging, Als, Alzheimer, Heart Failure, Ms |
| Interactions | TREX1, CGAS, STING, UBIQUITIN, DNA, GENES |
| KG Connections | 46 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TRIM24["<b>TRIM24</b>"]
Cancer{"Cancer"}
TRIM24 -->|"therapeutic target"| Cancer
Als{"Als"}
TRIM24 -->|"therapeutic target"| Als
Alzheimer{"Alzheimer"}
TRIM24 -->|"associated with"| Alzheimer
TRIM24 -->|"associated with"| Als
Ms{"Ms"}
TRIM24 -->|"associated with"| Ms
TDP1["TDP1"]
TRIM24 -->|"therapeutic target"| TDP1
MAPK1["MAPK1"]
TRIM24 -->|"therapeutic target"| MAPK1
GENES["GENES"]
TRIM24 -->|"therapeutic target"| GENES
CTSD["CTSD"]
TRIM24 -->|"therapeutic target"| CTSD
HIF1A["HIF1A"]
TRIM24 -->|"therapeutic target"| HIF1A
Wnt(["Wnt"])
TRIM24 -->|"therapeutic target"| Wnt
Nf__b(["Nf-Kappab"])
TRIM24 -->|"therapeutic target"| Nf__b
NFKB1["NFKB1"]
NFKB1 -->|"therapeutic target"| TRIM24
ERK["ERK"]
ERK -->|"therapeutic target"| TRIM24
DUSP10["DUSP10"]
DUSP10 -->|"associated with"| TRIM24
MAP1S["MAP1S"]
MAP1S -->|"associated with"| TRIM24
PSP["PSP"]
PSP -->|"associated with"| TRIM24
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"associated with"| TRIM24
ASTROCYTES["ASTROCYTES"]
ASTROCYTES -->|"associated with"| TRIM24
SP1["SP1"]
SP1 -->|"associated with"| TRIM24
APOE["APOE"]
APOE -->|"associated with"| TRIM24
TAU["TAU"]
TAU -->|"associated with"| TRIM24
KIF13A["KIF13A"]
KIF13A -->|"associated with"| TRIM24
style TRIM24 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Aging | implicated_in | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Cardiac | regulates | disease | 0.65 |
| Heart Failure | implicated_in | disease | 0.65 |
| TDP1 | therapeutic_target | gene | 0.60 |
| MAPK1 | therapeutic_target | gene | 0.60 |
| CTSD | therapeutic_target | gene | 0.60 |
| HIF1A | therapeutic_target | gene | 0.60 |
| STX6 | associated_with | gene | 0.60 |
| MAPT | associated_with | gene | 0.60 |
| TREX1 | activates | gene | 0.60 |
| CGAS | inhibits | gene | 0.60 |
| STING | inhibits | gene | 0.60 |
| UBIQUITIN | activates | gene | 0.60 |
| RYR2 | regulates | gene | 0.60 |
| GENES | therapeutic_target | gene | 0.60 |
| Wnt | therapeutic_target | pathway | 0.60 |
| Nf-Κb | therapeutic_target | pathway | 0.60 |
| Mapk | therapeutic_target | pathway | 0.60 |
| DNA | inhibits | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| Calcium Signaling | implicated_in | pathway | 0.60 |
| Stem Cell | implicated_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NFKB1 | therapeutic_target | gene | 0.60 |
| DUSP10 | associated_with | gene | 0.60 |
| MAP1S | associated_with | gene | 0.60 |
| PSP | associated_with | gene | 0.60 |
| SP1 | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| TAU | associated_with | gene | 0.60 |
| KIF13A | associated_with | gene | 0.60 |
| TP53 | inhibits | gene | 0.60 |
| ERK | therapeutic_target | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| ASTROCYTES | associated_with | gene | 0.60 |
| DSDNA | inhibits | gene | 0.60 |
| P53 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||