gene

TRIM24

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRIM24: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

46Connections
0Hypotheses
0Analyses
32Outgoing
14Incoming

Summary

TRIM24 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, inhibits. Associated with Aging, Als, Alzheimer. Connected to 47 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolTRIM24
Full NameTripartite Motif Containing 24
Chromosome7q33
Protein TypeLigase
Functionis a transcriptional coactivator and E3 ubiquitin ligase that plays key roles in gene regulation, DNA damage response, and cellular stress responses [1](https://pubmed.
Primary Expressionvarious cancers:
Amino Acids008 aa
Exons17
UniProt ID[Q9Y2X9](https://www.uniprot.org/uniprot/Q9Y2X9)
Ensembl IDENSG00000108344
OMIM603546
GeneCardsTRIM24
Human Protein AtlasTRIM24
RING fingerA C3HC4 RING domain with E3 ubiquitin ligase activity
B boxesTwo B-box domains involved in protein-protein interactions
Associated DiseasesAging, Als, Alzheimer, Heart Failure, Ms
InteractionsTREX1, CGAS, STING, UBIQUITIN, DNA, GENES
KG Connections46 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

TRIM24 — Tripartite Motif Containing 24

gene · 1425 words

DUSP10 Gene

gene · 1018 words

MAP1S - Microtubule Associated Protein 1S

gene · 712 words

KIF13A Gene

gene · 560 words

Genes

index · 271 words

Pathway Diagram

graph TD
    TRIM24["<b>TRIM24</b>"]
    Cancer{"Cancer"}
    TRIM24 -->|"therapeutic target"| Cancer
    Als{"Als"}
    TRIM24 -->|"therapeutic target"| Als
    Alzheimer{"Alzheimer"}
    TRIM24 -->|"associated with"| Alzheimer
    TRIM24 -->|"associated with"| Als
    Ms{"Ms"}
    TRIM24 -->|"associated with"| Ms
    TDP1["TDP1"]
    TRIM24 -->|"therapeutic target"| TDP1
    MAPK1["MAPK1"]
    TRIM24 -->|"therapeutic target"| MAPK1
    GENES["GENES"]
    TRIM24 -->|"therapeutic target"| GENES
    CTSD["CTSD"]
    TRIM24 -->|"therapeutic target"| CTSD
    HIF1A["HIF1A"]
    TRIM24 -->|"therapeutic target"| HIF1A
    Wnt(["Wnt"])
    TRIM24 -->|"therapeutic target"| Wnt
    Nf__b(["Nf-Kappab"])
    TRIM24 -->|"therapeutic target"| Nf__b
    NFKB1["NFKB1"]
    NFKB1 -->|"therapeutic target"| TRIM24
    ERK["ERK"]
    ERK -->|"therapeutic target"| TRIM24
    DUSP10["DUSP10"]
    DUSP10 -->|"associated with"| TRIM24
    MAP1S["MAP1S"]
    MAP1S -->|"associated with"| TRIM24
    PSP["PSP"]
    PSP -->|"associated with"| TRIM24
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"associated with"| TRIM24
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"associated with"| TRIM24
    SP1["SP1"]
    SP1 -->|"associated with"| TRIM24
    APOE["APOE"]
    APOE -->|"associated with"| TRIM24
    TAU["TAU"]
    TAU -->|"associated with"| TRIM24
    KIF13A["KIF13A"]
    KIF13A -->|"associated with"| TRIM24
    style TRIM24 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (32)

TargetRelationTypeStr
Cancertherapeutic_targetdisease0.65
Alstherapeutic_targetdisease0.65
Alzheimerassociated_withdisease0.65
Alsassociated_withdisease0.65
Msassociated_withdisease0.65

Incoming (14)

SourceRelationTypeStr
NFKB1therapeutic_targetgene0.60
DUSP10associated_withgene0.60
MAP1Sassociated_withgene0.60
PSPassociated_withgene0.60
SP1associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found