Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TMEM230: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | TMEM230 |
| Full Name | Transmembrane Protein 230 |
| Chromosome | 20p13 |
| Protein Family | TMEM230/C20orf30 family |
| Function | encodes a transmembrane protein localized primarily to synaptic vesicles, endosomes, and mitochondria [@tmem230_pd]. |
| Molecular Weight | 25 kDa |
| Amino Acids | 175 aa |
| Pathways | Apoptosis, Dna Repair, Glycolysis, Oxidative Phosphorylation, glycosylation |
| UniProt ID | Q9H0Y7 |
| NCBI Gene ID | 138802 |
| Ensembl ID | ENSG00000167840 |
| GeneCards | TMEM230 |
| Human Protein Atlas | TMEM230 |
| Inheritance Pattern | Autosomal Dominant |
| Age of Onset | 45-55 years (familial cases) |
| Associated Diseases | Parkinson's disease |
| Interactions | AKT, PI3K, MTOR |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
TMEM230["TMEM230"]
glycosylation["glycosylation"]
TMEM230 -->|"regulates"| glycosylation
unfolded_protein_response["unfolded protein response"]
TMEM230 -->|"regulates"| unfolded_protein_response
neurodegeneration["neurodegeneration"]
TMEM230 -->|"implicated in"| neurodegeneration
style TMEM230 fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7| Target | Relation | Type | Str |
|---|---|---|---|
| glycosylation | regulates | process | 0.85 |
| glycan synthesis | regulates | biological_process | 0.80 |
| glycan processing | regulates | biological_process | 0.80 |
| unfolded protein response | regulates | process | 0.80 |
| Aging | regulates | disease | 0.65 |
| Tumor | regulates | disease | 0.65 |
| Senescence | regulates | disease | 0.65 |
| Parkinson | regulates | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Autoimmune | inhibits | disease | 0.65 |
| Unfolded Protein Response | inhibits | pathway | 0.60 |
| Glycolysis | regulates | pathway | 0.60 |
| Oxidative Phosphorylation | regulates | pathway | 0.60 |
| Mtor | inhibits | pathway | 0.60 |
| Dna Repair | regulates | pathway | 0.60 |
| Apoptosis | regulates | pathway | 0.60 |
| PI3K-AKT-mTOR signaling | participates_in | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||