concept

PGC1ALPHA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PGC1ALPHA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

1Hypotheses

1Analyses

27Outgoing

10Incoming

1Experiments

8Debates

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💡 Concept Info

Name	PGC1ALPHA
Key Genes/Proteins	ALPHA-SYNUCLEIN, App, DJ-1, DJ1, HNRNPA1, LMX1B
Related Diseases	Alzheimer, Amyotrophic Lateral Sclerosis, Huntington, HUNTINGTON'S DISEASE, Neurodegeneration
Related Pathways	Alpha-Synuclein, Amyloid, Er Stress

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PGC-1α (PPARGC1A)

protein · 2474 words

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Pathway Diagram

graph TD
    PGC1ALPHA["PGC1ALPHA"]
    PGC1ALPHA -->|"regulates"| Parkinson["Parkinson"]
    PGC1ALPHA -->|"regulates"| NURR1["NURR1"]
    PGC1ALPHA -->|"regulates"| PARK7["PARK7"]
    PGC1ALPHA -->|"regulates"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PGC1ALPHA -->|"regulates"| ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    PGC1ALPHA -->|"regulates"| Synaptic_Plasticity["Synaptic Plasticity"]
    PGC1ALPHA -->|"regulates"| Er_Stress["Er Stress"]
    PGC1ALPHA -->|"regulates"| Alpha_Synuclein["Alpha-Synuclein"]
    LMX1B["LMX1B"] -->|"regulates"| PGC1ALPHA
    PINK1["PINK1"] -->|"regulates"| PGC1ALPHA
    PARKINSON["PARKINSON"] -->|"regulates"| PGC1ALPHA
    SNCA["SNCA"] -->|"regulates"| PGC1ALPHA
    SFPQ["SFPQ"] -->|"regulates"| PGC1ALPHA
    DJ_1["DJ-1"] -->|"regulates"| PGC1ALPHA
    AND["AND"] -->|"regulates"| PGC1ALPHA
    NFM["NFM"] -->|"regulates"| PGC1ALPHA

Outgoing (27)

Target	Relation	Type	Str
mitochondrial biogenesis	regulates	process	0.90
HUNTINGTON'S DISEASE	downregulates	disease	0.80
Huntington	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
DJ1	regulates	gene	0.60
PARKIN	regulates	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
ALPHA-SYNUCLEIN	regulates	gene	0.60
Synaptic Plasticity	regulates	pathway	0.60
NURR1	regulates	gene	0.60
Alpha-Synuclein	regulates	pathway	0.60
DJ-1	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
Dopaminergic	regulates	cell_type	0.60
App	regulates	protein	0.60
Oxidative Stress	regulates	pathway	0.60
Amyloid	regulates	pathway	0.60
Er Stress	regulates	pathway	0.60
PARK7	regulates	gene	0.60
LMX1B	regulates	gene	0.60
HNRNPA1	regulates	gene	0.60
SNCA	regulates	gene	0.60
PINK1	regulates	gene	0.60
NFM	regulates	gene	0.60

Incoming (10)

Source	Relation	Type	Str
SIRT1	activates	protein	0.90
PINK1	regulates	gene	0.60
SNCA	regulates	gene	0.60
LMX1B	regulates	gene	0.60
NFM	regulates	gene	0.60
HNRNPA1	regulates	gene	0.60
SFPQ	regulates	gene	0.60
PARK7	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
DJ-1	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SIRT1 Activation Couples Mitochondrial Biogenesis to Ferropt	0.824	neurodegeneration	Can ferroptosis inhibitors prevent BBB d

Mentioning Analyses (1)

Scientific analyses that reference this entity

Senescent cell clearance as neurodegeneration therapy

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.769

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Irisin effects on osteogenic differentiation in mesenchymal stem cells	exploratory	bone fracture	0.900	0.00	mouse bone mesenchymal stem ce	proposed	N/A

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018