Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PARKIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PARKIN is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, interacts with. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 1659 entities in the SciDEX knowledge graph.
| Gene Symbol | PARK2 |
| Aliases | PARKIN |
| Chromosome | 6q26 |
| Protein Type | Ligase |
| Function | Parkin is a cytosolic E3 ubiquitin ligase essential for mitochondrial maintenance and quality control. |
| Primary Expression | AD brain - Parkin can degrade amyloid precursor protein (APP) fragments - May affect tau phosphorylation through ubiquitin-dependent pathways[@burns20 |
| Pathways | Adaptive Immunity, Amyloid, Apoptosis, Autophagy, Cell Cycle |
| UniProt ID | O60260 |
| NCBI Gene ID | 5071 |
| Ensembl ID | ENSG00000185358 |
| GeneCards | PARK2 |
| Human Protein Atlas | PARK2 |
| PINK1 | Phosphorylation |
| UBC6, UBC7 | E2 enzyme |
| p62/SQSTM1 | Binding |
| Associated Diseases | ALS, Aging, Alzheimer, Alzheimer'S Disease |
| Known Drugs/Compounds | DEFERIPRONE, epigallocatechin gallate, RAPAMYCIN, RESVERATROL, Lycopene, Canagliflozin |
| Interactions | FMR1, SNCA, FAM134B, LC3, EPAS1, MIRO1 |
| KG Connections | 2935 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
PARKIN["PARKIN"] -->|"interacts"| Dementia["Dementia"]
PARKIN["PARKIN"] -->|"interacts"| Cardiovascular["Cardiovascular"]
PARKIN["PARKIN"] -->|"interacts"| Als["Als"]
PARKIN["PARKIN"] -->|"interacts"| Alzheimer["Alzheimer"]
PARKIN["PARKIN"] -->|"interacts"| Parkinson["Parkinson"]
PARKIN["PARKIN"] -->|"interacts"| Ms["Ms"]
PINK1["PINK1"] -->|"activates"| PARKIN["PARKIN"]
AMPK["AMPK"] -->|"phosphorylates"| PARKIN["PARKIN"]
CAT["CAT"] -->|"interacts"| PARKIN["PARKIN"]
OPTN["OPTN"] -->|"interacts"| PARKIN["PARKIN"]
style PARKIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| PINK1 | regulates | gene | 1.00 |
| PINK1 | activates | gene | 1.00 |
| PINK1 | associated_with | gene | 1.00 |
| Als | regulates | disease | 1.00 |
| Mitophagy | regulates | pathway | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Mitochondrial Function | activates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| Mitophagy | inhibits | pathway | 1.00 |
| Aging | activates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Cancer | regulates | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| Parkinson | regulates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Neurodegeneration | therapeutic_target | disease | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| MITOPHAGY | regulates | gene | 1.00 |
| Parkinson | activates | disease | 1.00 |
| MITOCHONDRIA | activates | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| Apoptosis | regulates | pathway | 1.00 |
| Inflammasome | activates | pathway | 1.00 |
| Mitochondrial Function | implicated_in | pathway | 1.00 |
| PTEN | activates | gene | 0.98 |
| PARKINSON_DISEASE | associated_with | gene | 0.95 |
| OXSM | polyubiquitinates | protein | 0.95 |
| Mitochondrial Quality Control | involved_in | process | 0.95 |
| Ubiquitin-Dependent Mitophagy | regulates | pathway | 0.95 |
| Als | interacts_with | disease | 0.95 |
| Als | associated_with | disease | 0.95 |
| Parkinson | therapeutic_target | disease | 0.95 |
| Als | inhibits | disease | 0.95 |
| ALPHA-SYNUCLEIN | regulates | gene | 0.95 |
| NEURODEGENERATION | protects_against | gene | 0.95 |
| Tumor | activates | disease | 0.95 |
| Tumor | inhibits | disease | 0.95 |
| Inflammation | regulates | disease | 0.95 |
| Cardiac | regulates | disease | 0.95 |
| Cancer | inhibits | disease | 0.95 |
| Als | implicated_in | disease | 0.95 |
| Parkinson | implicated_in | disease | 0.95 |
| Alzheimer | implicated_in | disease | 0.95 |
| MITOCHONDRIAL HOMEOSTASIS | regulates | entity | 0.95 |
| MITOPHAGY | mediates | entity | 0.95 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PINK1 | activates | protein | 1.00 |
| PINK1 | regulates | protein | 1.00 |
| PTEN | activates | gene | 1.00 |
| PINK1 | associated_with | gene | 1.00 |
| PINK1 | inhibits | gene | 1.00 |
| UBIQUITIN | associated_with | gene | 1.00 |
| UBIQUITIN | activates | gene | 1.00 |
| UBIQUITIN | regulates | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| PARKINSON'S DISEASE | activates | gene | 1.00 |
| MITOPHAGY | activates | gene | 1.00 |
| MITOPHAGY | associated_with | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| MITOCHONDRIA | regulates | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| MITOCHONDRIA | activates | gene | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| PARKINSON | associated_with | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| PARKINSON | activates | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| MITOCHONDRIA | implicated_in | gene | 1.00 |
| MITOCHONDRIA | inhibits | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| PINK1 | implicated_in | gene | 1.00 |
| UBIQUITIN | inhibits | gene | 1.00 |
| SIRT1 | activates | gene | 1.00 |
| PARKINSON'S DISEASE | regulates | gene | 1.00 |
| NEURODEGENERATION | therapeutic_target | gene | 1.00 |
| PARKINSON | regulates | gene | 1.00 |
| LRRK2 | associated_with | gene | 0.98 |
| MITOPHAGY | regulates | gene | 0.98 |
| PINK1 | phosphorylates | gene | 0.95 |
| FUMARATE | inhibits | entity | 0.92 |
| PCK2 | inhibits | protein | 0.92 |
| PINK1 | upstream_of | protein | 0.90 |
| IL17A | inhibits | gene | 0.90 |
| PRDX6 | interacts_with | protein | 0.90 |
| MIF | inhibits | protein | 0.90 |
| AMYLOID | associated_with | disease | 0.90 |
| SQSTM1 | regulates | gene | 0.90 |
| PRKN | associated_with | gene | 0.90 |
| NLRP3 | activates | gene | 0.90 |
| NEURODEGENERATION | activates | gene | 0.90 |
| AUTOPHAGY | inhibits | gene | 0.90 |
| MITOCHONDRIA | interacts_with | gene | 0.90 |
| NEURODEGENERATION | causes | disease | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK | 0.509 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor | 0.418 | neurodegeneration | Mitochondrial transfer between neurons a |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.586
neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.632
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.467
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-11 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| SIRT1 activation by SRT2104 enhances mitophagy and reduces senescence in auditor [PMID:41593189] | ["Cho S", "Jo E", "Jang H"] | Scientific reports | 2026 | 0 |
| Targeted nanovesicular delivery of dexmedetomidine modulates microglial lysosoma [PMID:41778730] | Zhang Y, Jiang H, Zhang F, Liao J | Neural regeneration research | 2026 | 0 |
| The myocardial ischemic cascade network and multi-target synergistic interventio [PMID:41544859] | Qi L, Yi J, Shen Y, Jiang H, Yao X et al | Biochem Pharmacol | 2026 | 0 |
| Homoplantaginin ameliorates osteoarthritis by activating Sirt3/PINK1/Parkin sign [PMID:41720004] | Zhang H, Xiao J, Yi Y, Chen B, Lv W et a | Phytomedicine | 2026 | 0 |
| Kakkalide promotes spinal cord injury repair by regulating microglial M2 polariz [PMID:41720005] | You T, Dai B, Ding X, He Z, Peng J et al | Phytomedicine | 2026 | 0 |
| AARS2 R199C mutation induces lactylation-driven premature ovarian insufficiency [PMID:41832996] | Zhang HH, Zhang ZL, Xu W | Reproduction | 2026 | 0 |
| Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Indu [PMID:41905969] | Wang Y, Yuan Q | Clin Exp Pharmacol Physiol | 2026 | 0 |
| FGFR1 suppresses ovarian cancer progression by modulating SIRT3-dependent lactyl [PMID:41946672] | Jiang F, Huang H, Dong Z, Zhang L, Zhang | Cell Death Discov | 2026 | 0 |
| Adipocyte small extracellular vesicle-derived microRNA-30a-3p exacerbates hepati [PMID:41965824] | Zhang T, Hu L, Chen D, Chen Y, Zhou F et | Nat Commun | 2026 | 0 |
| α7-nAChR activation mitigates pyridaben-induced hepatotoxicity in grass carp (Ct [PMID:41966317] | Wu C, Jiang J, Qiu H, Xie J, Li S | Fish Shellfish Immunol | 2026 | 0 |
| Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated [PMID:41896899] | Fang Y, Deng M, Huang K, Song H, Chu Y, | Cell communication and signali | 2026 | 0 |
| Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via P [PMID:41906653] | Xu Z, Cui X, Chu H, Wan H, Xie Y, Wang Y | Journal of diabetes | 2026 | 0 |
| Inhibition of mitochondrial ROS turns LC3-associated phagocytosis to autophagy u [PMID:41896101] | Cheng YL, Su MS, Liao CC, Chang TW, Hsie | Journal of microbiology, immun | 2026 | 0 |
| Hyperoside stabilizes ACAT1 to promote fatty acid oxidation and attenuate kidney [PMID:41903436] | Shan C, Szili-Torok T, Yue G, Zhang L, M | Phytomedicine : international | 2026 | 0 |
| Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promotin [PMID:41897550] | ["Gao L", "Shen J", "Gao J", "Li T", "Ya | Antioxidants (Basel, Switzerla | 2026 | 0 |
| Comprehensive Insights Into Mitophagy: Mechanisms, Disease Associations, and The [PMID:40714832] | ["Tang M", "Outissint I", "Chen Y", "Gon | Journal of cellular biochemist | 2025 | 0 |
| Sirtuins as mediators and targets of arsenic toxicity: unraveling signaling path [PMID:40844627] | El-Mahrouk SR, El-Kadi AOS | Archives of toxicology | 2025 | 0 |
| Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinf [PMID:40089796] | Liu C, Zhao Y, Zhang W, Dao JJ, Li Q, Hu | Journal of neuroinflammation | 2025 | 0 |
| Phenylpropanoids of Eleutherococcus senticosus (Rupr. & maxim.) maxim. Alleviate [PMID:40081261] | Yang R, Meng X, Zhao W, Xu SQ, Wang SY, | Bioorganic chemistry | 2025 | 0 |
| Small molecule DDQ involvement of ERK-mediated signaling pathway with enhanced m [PMID:40222458] | Pradeepkiran JA, Kshirsagar S, Alvir RV, | Biochimica et biophysica acta. | 2025 | 0 |