Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DEXAMETHASONE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | DEXAMETHASONE |
| Key Genes/Proteins | SQSTM1, STING, ALPHA-SYNUCLEIN, APP |
| Related Diseases | CANCER, CHOLESTEROL, SARCOPENIA, FIBROSIS |
Knowledge base pages for this entity
graph TD
DEXAMETHASONE["DEXAMETHASONE"]
DEXAMETHASONE -->|"downregulates"| KCNK2["KCNK2"]
DEXAMETHASONE -->|"causes"| Ocular_Hypertension["Ocular Hypertension"]
DEXAMETHASONE -->|"upregulates"| FSP1["FSP1"]
DEXAMETHASONE -->|"causes"| Glucocorticoid_Induced_Ocular_["Glucocorticoid-Induced Ocular Hypertension"]
DEXAMETHASONE -->|"causes"| Glucocorticoid_Induced_Muscle_["Glucocorticoid-Induced Muscle Atrophy"]
DEXAMETHASONE -->|"modulates"| Trabecular_Meshwork["Trabecular Meshwork"]
DEXAMETHASONE -->|"causes"| Trabecular_Meshwork_Cell_Depol["Trabecular Meshwork Cell Depolarization"]
DEPRESSION["DEPRESSION"] -->|"inhibits"| DEXAMETHASONE| Target | Relation | Type | Str |
|---|---|---|---|
| KCNK2 | downregulates | entity | 0.95 |
| CANCER | activates | disease | 0.70 |
| MACROPHAGES | regulates | cell_type | 0.70 |
| SQSTM1 | interacts_with | gene | 0.70 |
| CHOLESTEROL | activates | phenotype | 0.70 |
| STING | inhibits | gene | 0.65 |
| SARCOPENIA | activates | disease | 0.65 |
| ALPHA-SYNUCLEIN | inhibits | protein | 0.65 |
| ALPHA-SYNUCLEIN | activates | protein | 0.65 |
| CANCER | associated_with | disease | 0.50 |
| MACROPHAGES | associated_with | cell_type | 0.50 |
| SQSTM1 | associated_with | gene | 0.50 |
| APP | associated_with | gene | 0.50 |
| CHOLESTEROL | associated_with | phenotype | 0.50 |
| ABCA1 | associated_with | gene | 0.50 |
| FIBROSIS | associated_with | disease | 0.50 |
| OSTEOBLASTS | associated_with | cell_type | 0.50 |
| INFLIXIMAB | associated_with | drug | 0.45 |
| DEPRESSION | associated_with | disease | 0.45 |
| TNF | associated_with | gene | 0.45 |
| SARCOPENIA | associated_with | disease | 0.45 |
| IL-6 | inhibits | gene | 0.35 |
| TNF | inhibits | gene | 0.35 |
| Source | Relation | Type | Str |
|---|---|---|---|
| FIBROSIS | inhibits | disease | 0.65 |
| APP | stabilizes | gene | 0.60 |
| ALPHA-SYNUCLEIN | associated_with | protein | 0.50 |
| DEPRESSION | associated_with | disease | 0.45 |
| DEPRESSION | inhibits | disease | 0.35 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||