disease

spinal muscular atrophy

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about spinal muscular atrophy: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

310Connections

0Hypotheses

0Analyses

45Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	TNF, CRH, LDL, LDLR, DNA, RNA, CLU, GFAP
Therapeutic Agents	dexamethasone, quercetin, statins
KG Connections	210 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

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Pathway Diagram

graph TD
    spinal_muscular_atrophy["spinal muscular atrophy"] -->|"disrupts"| endoplasmic_reticulum["endoplasmic reticulum"]
    style endoplasmic_reticulum fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    spinal_muscular_atrophy["spinal muscular atrophy"] -->|"disrupts"| mitochondria["mitochondria"]
    style mitochondria fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    spinal_muscular_atrophy["spinal muscular atrophy"] -->|"disrupts"| lysosome["lysosome"]
    style lysosome fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    spinal_muscular_atrophy["spinal muscular atrophy"] -->|"affects"| neural_stem_cells["neural stem cells"]
    style neural_stem_cells fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    spinal_muscular_atrophy["spinal muscular atrophy"] -->|"affects"| neurons["neurons"]
    style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    spinal_muscular_atrophy["spinal muscular atrophy"] -->|"disrupts"| glutamate["glutamate"]
    style glutamate fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    spinal_muscular_atrophy["spinal muscular atrophy"] -->|"involves"| unfolded_protein_response["unfolded protein response"]
    style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    MAPT["MAPT"] -->|"biomarker for"| spinal_muscular_atrophy["spinal muscular atrophy"]
    style MAPT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    LDL["LDL"] -->|"associated"| spinal_muscular_atrophy["spinal muscular atrophy"]
    style LDL fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    DNA["DNA"] -->|"associated"| spinal_muscular_atrophy["spinal muscular atrophy"]
    style DNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    GFAP["GFAP"] -->|"biomarker for"| spinal_muscular_atrophy["spinal muscular atrophy"]
    style GFAP fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    RNA["RNA"] -->|"activates"| spinal_muscular_atrophy["spinal muscular atrophy"]
    style RNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style spinal_muscular_atrophy fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (63)

Target	Relation	Type	Str
neural stem cells	affects	cell_type	0.90
neurons	affects	cell_type	0.90
unfolded protein response	involves	pathway	0.90
macrophages	affects	cell_type	0.90
lipid metabolism	involves	pathway	0.90
ferroptosis	involves	pathway	0.90
endosome	disrupts	organelle	0.90
B cells	affects	cell_type	0.80
T cells	affects	cell_type	0.80
cerebellum	affects	brain_region	0.80
astrocytes	affects	cell_type	0.80
TGF-beta signaling	involves	pathway	0.80
microglia	affects	cell_type	0.80
necroptosis	involves	pathway	0.80
pyroptosis	involves	pathway	0.80
hippocampus	affects	brain_region	0.80
Golgi apparatus	disrupts	organelle	0.80
glutamate signaling	involves	pathway	0.70
oligodendrocytes	affects	cell_type	0.70
cortex	affects	brain_region	0.70
spinal cord	affects	brain_region	0.70
axon	disrupts	organelle	0.70
blood-brain barrier	affects	brain_region	0.70
autophagy pathway	involves	pathway	0.60
substantia nigra	affects	brain_region	0.60
monocytes	affects	cell_type	0.60
dendritic cells	affects	cell_type	0.60
PI3K-AKT-mTOR signaling	involves	pathway	0.60
Wnt signaling	involves	pathway	0.60
adenosine	disrupts	neurotransmitter	0.60
thalamus	affects	brain_region	0.60
hypothalamus	affects	brain_region	0.60
nitric oxide	disrupts	neurotransmitter	0.60
oxidative stress response	involves	pathway	0.60
epigenetic regulation	involves	pathway	0.60
temporal lobe	affects	brain_region	0.60
insulin signaling	involves	pathway	0.60
insulin receptor	involves	receptor	0.60
endothelial cells	affects	cell_type	0.60
mast cells	affects	cell_type	0.60
synaptic vesicle	disrupts	organelle	0.60
Purkinje cells	affects	cell_type	0.60
choroid plexus	affects	brain_region	0.60
white matter	affects	brain_region	0.60
synaptic plasticity	involves	pathway	0.60

Incoming (247)

Source	Relation	Type	Str
MAPT	biomarker_for	gene	0.80
LDL	associated_with	gene	0.80
DNA	associated_with	gene	0.80
GFAP	biomarker_for	gene	0.80
RNA	activates	gene	0.70
TNF	associated_with	gene	0.70
LDLR	associated_with	gene	0.70
RNA	associated_with	gene	0.70
ALS	associated_with	gene	0.70
RNA	interacts_with	gene	0.70
DDC	biomarker_for	gene	0.70
IL6	regulates	gene	0.70
TNF	activates	gene	0.70
SLC16A1	transported_by	gene	0.60
FCGRT	activates	gene	0.60
FCGRT	protects_against	gene	0.60
TNF	inhibits	gene	0.60
dexamethasone	treats	compound	0.60
TNF	suppresses	gene	0.60
MMP2	inhibits	gene	0.60
MMP9	inhibits	gene	0.60
ULK1	activates	gene	0.60
DNMT1	activates	gene	0.60
MAP1LC3	activates	gene	0.60
ACTB	activates	gene	0.60
ATG7	activates	gene	0.60
BECN1	activates	gene	0.60
HTT	activates	gene	0.60
LC3	activates	gene	0.60
GABA	activates	gene	0.60
GABARAP	activates	gene	0.60
SQSTM1	activates	gene	0.60
MTORC1	activates	gene	0.60
DNA	activates	gene	0.60
SETX	activates	gene	0.60
TFEB	activates	gene	0.60
ULK1	regulates	gene	0.60
DNMT1	regulates	gene	0.60
MAP1LC3	regulates	gene	0.60
ACTB	regulates	gene	0.60
ATG7	regulates	gene	0.60
BECN1	regulates	gene	0.60
HTT	regulates	gene	0.60
LC3	regulates	gene	0.60
GABA	regulates	gene	0.60
GABARAP	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
MTORC1	regulates	gene	0.60
RNA	regulates	gene	0.60
DNA	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

spinal muscular atrophy

Understanding Entity Pages

Wiki Pages (20)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

ALS Failed Approaches Analysis

Blood-Brain Barrier Biology and Crossing Strategies

TRA2B Protein - Transformer-2 Beta

Splice-Modulating Therapies for Neurodegeneration

Gemin-8 Protein

Neuroprotection Strategies in Neurodegeneration

RNA Therapeutics for Neurodegeneration Investment Landscape

BIIB080 (MAPTRx) Antisense Oligonucleotide for Alzheimer's Disease

ubiquitin-proteasome-dysfunction-neurodegeneration

CNTFR Gene

Viral Vector Delivery Investment Landscape for Neurodegeneration

RNA-Targeted Therapies in Neurodegeneration

aav-gene-therapy-neurodegeneration

Arbor Biotechnologies

Section 106: Gene Therapy Vectors in CBS/PSP

Stathmin-2 (SCG10)

Diseases