concept

SPINAL MUSCULAR ATROPHY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPINAL MUSCULAR ATROPHY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

306Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

No summary available yet.

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💡 Concept Info

Name	SPINAL MUSCULAR ATROPHY
Key Genes/Proteins	TARDBP, TH
Related Pathways	DNA DAMAGE RESPONSE

Pathway Diagram

graph TD
    SPINAL_MUSCULAR_ATROPHY["SPINAL MUSCULAR ATROPHY"]
    SPINAL_MUSCULAR_ATROPHY -->|"regulates"| Fibroblast["Fibroblast"]
    SPINAL_MUSCULAR_ATROPHY -->|"target for"| Cholesterol["Cholesterol"]
    SPINAL_MUSCULAR_ATROPHY -->|"target for"| Neuron["Neuron"]
    SPINAL_MUSCULAR_ATROPHY -->|"expressed in"| Apoptosis["Apoptosis"]
    Gene_Therapy["Gene Therapy"] -->|"treats"| SPINAL_MUSCULAR_ATROPHY
    Nursinersen["Nursinersen"] -->|"treats"| SPINAL_MUSCULAR_ATROPHY
    RNA["RNA"] -->|"target for"| SPINAL_MUSCULAR_ATROPHY
    ALS["ALS"] -->|"target for"| SPINAL_MUSCULAR_ATROPHY
    OVERVIEW["OVERVIEW"] -->|"target for"| SPINAL_MUSCULAR_ATROPHY
    DEMENTIA["DEMENTIA"] -->|"target for"| SPINAL_MUSCULAR_ATROPHY
    HUNTINGTON["HUNTINGTON"] -->|"target for"| SPINAL_MUSCULAR_ATROPHY
    PARKINSON["PARKINSON"] -->|"target for"| SPINAL_MUSCULAR_ATROPHY

Outgoing (63)

Target	Relation	Type	Str
neurons	affects	cell_type	0.90
neural stem cells	affects	cell_type	0.90
unfolded protein response	involves	pathway	0.90
macrophages	affects	cell_type	0.90
ferroptosis	involves	pathway	0.90
lipid metabolism	involves	pathway	0.90
endosome	disrupts	organelle	0.90
microglia	affects	cell_type	0.80
pyroptosis	involves	pathway	0.80
necroptosis	involves	pathway	0.80
hippocampus	affects	brain_region	0.80
T cells	affects	cell_type	0.80
astrocytes	affects	cell_type	0.80
TGF-beta signaling	involves	pathway	0.80
cerebellum	affects	brain_region	0.80
B cells	affects	cell_type	0.80
Golgi apparatus	disrupts	organelle	0.80
axon	disrupts	organelle	0.70
blood-brain barrier	affects	brain_region	0.70
cortex	affects	brain_region	0.70
oligodendrocytes	affects	cell_type	0.70
spinal cord	affects	brain_region	0.70
glutamate signaling	involves	pathway	0.70
adenosine	disrupts	neurotransmitter	0.60
monocytes	affects	cell_type	0.60
dendritic cells	affects	cell_type	0.60
PI3K-AKT-mTOR signaling	involves	pathway	0.60
Wnt signaling	involves	pathway	0.60
thalamus	affects	brain_region	0.60
hypothalamus	affects	brain_region	0.60
oxidative stress response	involves	pathway	0.60
epigenetic regulation	involves	pathway	0.60
temporal lobe	affects	brain_region	0.60
nitric oxide	disrupts	neurotransmitter	0.60
endothelial cells	affects	cell_type	0.60
mast cells	affects	cell_type	0.60
insulin receptor	involves	receptor	0.60
insulin signaling	involves	pathway	0.60
choroid plexus	affects	brain_region	0.60
synaptic vesicle	disrupts	organelle	0.60
Purkinje cells	affects	cell_type	0.60
synaptic plasticity	involves	pathway	0.60
autophagy pathway	involves	pathway	0.60
substantia nigra	affects	brain_region	0.60
white matter	affects	brain_region	0.60
Autophagy	associated_with	pathway	0.55
Apoptosis	associated_with	pathway	0.55
Cholesterol	therapeutic_target	pathway	0.55
Mtor	associated_with	pathway	0.55
Neuron	therapeutic_target	cell_type	0.55

Incoming (243)

Source	Relation	Type	Str
Gene Therapy	treats	process	0.95
Nursinersen	treats	drug	0.90
SMN1 mutations	causes	gene	0.90
SMN1	therapeutic_target_for	gene	0.90
22459677	cause	paper	0.90
MAPT	biomarker_for	gene	0.80
DNA	associated_with	gene	0.80
LDL	associated_with	gene	0.80
GFAP	biomarker_for	gene	0.80
CRISPR-Q system	therapeutic_target	compound	0.80
RNA	associated_with	gene	0.70
ALS	associated_with	gene	0.70
LDLR	associated_with	gene	0.70
DDC	biomarker_for	gene	0.70
TNF	associated_with	gene	0.70
RNA	activates	gene	0.70
TNF	activates	gene	0.70
IL6	regulates	gene	0.70
RNA	interacts_with	gene	0.70
DNAJA1	inhibits	gene	0.65
ALDH1A2	contributes_to	gene	0.65
HUNTINGTIN	associated_with	gene	0.65
SMN	causes	gene	0.65
DNAJB1	inhibits	gene	0.65
HSP70	inhibits	gene	0.65
DNAJB2	inhibits	gene	0.65
DNAJB6	inhibits	gene	0.65
TDP-43	associated_with	gene	0.65
CNTN4	expressed_in	gene	0.65
PLIN4	expressed_in	gene	0.65
MAP1LC3	associated_with	gene	0.65
ATXN2	associated_with	gene	0.65
BID	expressed_in	gene	0.65
TBC1D24	expressed_in	gene	0.65
CCNF	expressed_in	gene	0.65
MAPT	associated_with	gene	0.65
HNRNPA2B1	associated_with	gene	0.65
CDKN1A	expressed_in	gene	0.65
SMN	associated_with	gene	0.65
TIA1	associated_with	gene	0.65
HNRNPA1	associated_with	gene	0.65
OVERVIEW	therapeutic_target	gene	0.65
RNA	therapeutic_target	gene	0.65
ALS	therapeutic_target	gene	0.65
PYROPTOSIS	associated_with	gene	0.65
APOPTOSIS	associated_with	gene	0.65
FERROPTOSIS	associated_with	gene	0.65
HUNTINGTON	associated_with	gene	0.65
PARKINSON	associated_with	gene	0.65
STROKE	associated_with	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How can CRISPR systems achieve persistent therapeutic effects while avoiding chr

gene therapy | 2026-04-11 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate highlighted that long-term CRISPR expression triggers immune response

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning SPINAL MUSCULAR ATROPHY in their description or question text

No additional research found