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gene 3,742 words KG: SQSTM1
Contents

SQSTM1 — Sequestosome 1 (p62)

🧬 Gene Info
Gene SymbolSQSTM1
Full NameSequestosome 1 (p62)
Chromosome5q35.3.
Protein TypeProtein
Functionp62/SQSTM1 functions as: [@jones2021]
Molecular Weight~62 kDa (hence p62)
PathwaysAdaptive Immunity, Akt, Autophagy, Autophagy-lysosomal pathway, Cell Cycle
UniProt IDQ13501
GeneCardsSQSTM1
Human Protein AtlasSQSTM1
Associated DiseasesAD, ADH, Aging, ALI, Als
Known Drugs/CompoundsATC161, COENZYME Q10, DEXAMETHASONE, N-degrons, Palmostatin B, rapamycin
Interactions4E-BP1, ABCA1, ABCD3, ABCG1, ACAT1, ACHE
SciDEX HypothesesRutin enhances chaperone and autophagic clearance
Astrocytic SQSTM1 Overexpression Therapy
Cross-Seeding Autophagy Specificity Enhancement
KG Connections4054 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (19)

H2: Impaired Autophagy Receptor Recruitment Traps G3BP1 Gran
Score: 0.74C9orf72 DPRs Impair Autophagy Receptor Docking on Stress Gra
Score: 0.72NRF2-Mediated Proteostatic Convergence: Shared Oxidative Str
Score: 0.70Autophagy-Lysosomal Degradation of IBA1 in Stressed Microgli
Score: 0.68Autophagic Flux Enhancement Synergizes With Chaperones to Cl
Score: 0.65p62 Liquid-Liquid Phase Separation Nucleates Cross-Organelle
Score: 0.65Rutin enhances chaperone and autophagic clearance of misfold
Score: 0.60Neuronal Hypersensitivity to Feedback Inhibition by p62/Sequ
Score: 0.52GATA4 Stabilization and NF-κB Co-activation Identifies Senes
Score: 0.52Lamin B1 Degradation as Irreversibility Gate
Score: 0.49Liquid-Liquid Phase Separation (LLPS) Saturation Partitionin
Score: 0.46Chaperone-Autophagy Coupling Prevents Aggregate Persistence
Score: 0.38CHIP-mediated K63-linked ubiquitination promotes autophagoso
Score: 0.38CHIP-mediated K63-linked ubiquitination redirects oligomeric
Score: 0.38Chaperone-Autophagy Coupling Prevents Aggregate Persistence
Score: 0.38Synaptic-Selective Autophagy Receptor Expression to Bypass A
Score: 0.37Cross-Seeding Autophagy Specificity Enhancement
Score: 0.00Astrocytic SQSTM1 Overexpression Therapy
Score: 0.00Pharmacological Chaperone-Mediated Selective Autophagy
Score: 0.00

Knowledge Graph (12 edges)

SQSTM1 activates NFE2L2
SQSTM1 activates ULK1
SQSTM1 interacts_with SCAP
SIRT3 activates SQSTM1
SQSTM1 regulates STING1
ACTB regulates SQSTM1
PPARA regulates SQSTM1
CAT regulates SQSTM1
SQSTM1 regulates RPS6KB1
SQSTM1 regulates RAB7A

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