gene 819 words KG: ent-gene-1aae10b5
Contents

ATG7 Gene

🧬 Gene Info
Gene SymbolATG7
Full NameAutophagy Related 7
Chromosome3p22.1
Protein TypeProtein
Functionis an essential E1-like activating enzyme that plays a central role in the execution of macroautophagy.
Molecular Weight78 kDa
PathwaysAngiogenesis, Apoptosis, Autophagy, Camp Signaling, Cell Cycle
UniProt IDO95352
NCBI Gene ID9459
Ensembl IDENSG00000198271
OMIM607760
GeneCardsATG7
Human Protein AtlasATG7
Associated DiseasesAging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia
Known Drugs/Compoundscurcumin, CURCUMIN, nicotinamide, rapamycin, RAPAMYCIN
InteractionsACETYL-COA, ACHE, ACSL4, ACTB, Actin, AD
SciDEX HypothesesAstrocyte-specific autophagy deficiency induces NA
Autophagy Enhancement for Tau Clearance
Oligodendroglial Autophagy Enhancement
KG Connections1420 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (50)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Blood-Brain Barrier SPM Shuttle System
Score: 0.53
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.83
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Adenosine-Astrocyte Metabolic Reset
Score: 0.73
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71
Noradrenergic-Tau Propagation Blockade
Score: 0.71
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Autophagosome Maturation Checkpoint Control
Score: 0.71
Orexin-Microglia Modulation Therapy
Score: 0.71
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Lysosomal Enzyme Trafficking Correction
Score: 0.71
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
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Related Analyses (22)

Senescent cell clearance as neurodegeneration therapy
neurodegeneration · completed
Does TRPML1 enhancement cause therapeutic benefit or paradox
neurodegeneration · completed
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (6)

ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: biomarker_for
ACTB Gene
gene · KG edge: associated_with
AIF1 Gene
gene · KG edge: associated_with
AKT1 Gene
gene · KG edge: activates
Gene Page: ALS4 (SENATAXIN)
gene · KG edge: associated_with

Knowledge Graph (2 edges)

SDA-2026-04-16-hyp-4a6e22aa targets ent-gene-1aae10b5
ent-gene-1aae10b5 targeted_by SDA-2026-04-16-hyp-4a6e22aa

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