Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ATP6AP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
ATP6AP2 is a concept in neurodegeneration research. Key relationships include: associated with, regulates, participates in. Associated with Cancer, Cardiovascular, Ischemia. Connected to 62 entities in the SciDEX knowledge graph.
| Name | ATP6AP2 |
| Key Genes/Proteins | HDAC6, PSEN1 |
| Related Diseases | Cancer, Cardiovascular, Ischemia, Neurodegeneration, Parkinson |
| Related Pathways | lysosomal acidification, Amyloid, Autophagy, Mtor |
Knowledge base pages for this entity
graph TD
ATP6AP2["ATP6AP2"]
ATP6AP2 -->|"participates in"| lysosomal_acidification["lysosomal acidification"]
ATP6AP2 -->|"regulates"| Cancer["Cancer"]
ATP6AP2 -->|"regulates"| Cardiovascular["Cardiovascular"]
ATP6AP2 -->|"regulates"| Neurodegeneration["Neurodegeneration"]| Target | Relation | Type | Str |
|---|---|---|---|
| lysosomal acidification | participates_in | pathway | 0.80 |
| Cancer | regulates | disease | 0.65 |
| Cardiovascular | regulates | disease | 0.65 |
| Ischemia | associated_with | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Cardiovascular | associated_with | disease | 0.65 |
| Neurodegeneration | associated_with | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Amyloid | associated_with | pathway | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| Mtor | associated_with | pathway | 0.60 |
| HDAC6 | associated_with | gene | 0.60 |
| PSEN1 | associated_with | gene | 0.60 |
| MAP1LC3B | associated_with | gene | 0.60 |
| PIK3C3 | associated_with | gene | 0.60 |
| BECN1 | associated_with | gene | 0.60 |
| GABARAP | associated_with | gene | 0.60 |
| TFEB | associated_with | gene | 0.60 |
| VDAC2 | associated_with | gene | 0.60 |
| WDR45 | associated_with | gene | 0.60 |
| SOX9 | associated_with | gene | 0.60 |
| BCL2 | associated_with | gene | 0.60 |
| RAS | associated_with | gene | 0.60 |
| RAB9A | associated_with | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| LC3B | associated_with | gene | 0.60 |
| PSEN2 | associated_with | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| MTOR | associated_with | gene | 0.60 |
| GLA | associated_with | gene | 0.60 |
| APP | associated_with | gene | 0.60 |
| BCL2L1 | associated_with | gene | 0.60 |
| ESR2 | associated_with | gene | 0.60 |
| CYP19A1 | associated_with | gene | 0.60 |
| RNA | associated_with | gene | 0.60 |
| UVRAG | associated_with | gene | 0.60 |
| AMBRA1 | associated_with | gene | 0.60 |
| FYCO1 | associated_with | gene | 0.60 |
| AMPK | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| CTSD | associated_with | gene | 0.60 |
| GABA | associated_with | gene | 0.60 |
| ATG | associated_with | gene | 0.60 |
| ESR1 | associated_with | gene | 0.60 |
| NEURODEGENERATION | associated_with | gene | 0.60 |
| PRESENILIN | associated_with | gene | 0.60 |
| ULK1 | associated_with | gene | 0.60 |
| LAMP2 | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AMBRA1 | associated_with | gene | 0.60 |
| MTOR | associated_with | gene | 0.60 |
| PRESENILIN | associated_with | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| CTSD | associated_with | gene | 0.60 |
| ATG | associated_with | gene | 0.60 |
| ESR1 | associated_with | gene | 0.60 |
| PSEN2 | associated_with | gene | 0.60 |
| AMYLOID | associated_with | gene | 0.60 |
| AMPK | associated_with | gene | 0.60 |
| LAMP2 | associated_with | gene | 0.60 |
| ESR2 | associated_with | gene | 0.60 |
| ULK1 | associated_with | gene | 0.60 |
| NEURODEGENERATION | associated_with | gene | 0.60 |
| BCL2L1 | associated_with | gene | 0.60 |
| UVRAG | associated_with | gene | 0.60 |
| FYCO1 | associated_with | gene | 0.60 |
| APP | associated_with | gene | 0.60 |
| LC3B | associated_with | gene | 0.60 |
| GLA | associated_with | gene | 0.60 |
| SOX9 | associated_with | gene | 0.60 |
| MAP1LC3B | associated_with | gene | 0.60 |
| RAS | associated_with | gene | 0.60 |
| GABARAP | associated_with | gene | 0.60 |
| RAB9A | associated_with | gene | 0.60 |
| PIK3C3 | associated_with | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| VDAC2 | associated_with | gene | 0.60 |
| WDR45 | associated_with | gene | 0.60 |
| HDAC6 | associated_with | gene | 0.60 |
| RNA | associated_with | gene | 0.60 |
| GABA | associated_with | gene | 0.60 |
| TFEB | associated_with | gene | 0.60 |
| PSEN1 | associated_with | gene | 0.60 |
| BECN1 | associated_with | gene | 0.60 |
| WNT | regulates | gene | 0.60 |
| RANKL | activates | gene | 0.60 |
| WNT3A | regulates | gene | 0.60 |
| CYP19A1 | associated_with | gene | 0.60 |
| BCL2 | associated_with | gene | 0.60 |
| APP | activates | gene | 0.60 |
| AR | activates | gene | 0.60 |
| ATG | activates | gene | 0.60 |
| rapamycin | targets | drug | 0.60 |
| TFEB | activates | protein | 0.50 |
| AMBRA1 | activates | protein | 0.50 |
| Autophagy | activates | process | 0.50 |
| ULK1 | activates | gene | 0.50 |
| CTSD | activates | gene | 0.50 |
| UVRAG | activates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||