protein

PROGRANULIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PROGRANULIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

333Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Progranulin (GRN) is a secreted growth factor involved in neuronal survival, lysosomal function, and inflammation. GRN mutations cause frontotemporal dementia and are linked to Alzheimer's and Parkinson's disease.

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🔬 Protein Info

Gene Symbol	GRN
Aliases	PROGRANULIN
Chromosome	17q21.31
Protein Family	Progranulin family
Function	is a secreted glycoprotein encoded by the <a href="/genes/grn">GRN</a> gene that functions as a crucial regulator of neuronal survival, lysosomal function, and immune response[@baker2006].
Primary Expression	Secreted, Lysosomes, Cytoplasm
Subcellular Localization	Secreted, Lysosomes, Cytoplasm
Molecular Weight	90 kDa
Amino Acids	60 aa
Pathways	Immune Response, Inflammasome, Tdp-43, Toll-Like Receptor, inflammation
UniProt ID	P28799
GeneCards	GRN
Human Protein Atlas	GRN
Gene	GRN (Progranulin) located on chromosome 17q21.31
Protein	Progranulin, 593 amino acids (~63 kDa)
Associated Diseases	ALS, Dementia, FRONTOTEMPORAL DEMENTIA, Ftd
Interactions	CX3CR1, CXCL10, BDNF, FGF23, PLAU, VIM
KG Connections	328 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure: PROGRANULIN — PDB 2JYE Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PROGRANULIN["<b>PROGRANULIN</b>"]
    Neuroinflammation{"Neuroinflammation"}
    PROGRANULIN -->|"activates"| Neuroinflammation
    Aging{"Aging"}
    PROGRANULIN -->|"activates"| Aging
    Inflammation{"Inflammation"}
    PROGRANULIN -->|"activates"| Inflammation
    Alzheimer{"Alzheimer"}
    PROGRANULIN -->|"activates"| Alzheimer
    ALS{"ALS"}
    PROGRANULIN -->|"activates"| ALS
    Huntington{"Huntington"}
    PROGRANULIN -->|"activates"| Huntington
    Frontotemporal_Dementia{"Frontotemporal Dementia"}
    PROGRANULIN -->|"activates"| Frontotemporal_Dementia
    Dementia{"Dementia"}
    PROGRANULIN -->|"activates"| Dementia
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    PROGRANULIN -->|"activates"| Amyotrophic_Lateral_Sclerosis
    Parkinson{"Parkinson"}
    PROGRANULIN -->|"activates"| Parkinson
    Prion_Disease{"Prion Disease"}
    PROGRANULIN -->|"activates"| Prion_Disease
    Neurodegeneration{"Neurodegeneration"}
    PROGRANULIN -->|"activates"| Neurodegeneration
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    AMYOTROPHIC_LATERAL_SCLEROSIS -->|"activates"| PROGRANULIN
    TREM2["TREM2"]
    TREM2 -->|"activates"| PROGRANULIN
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| PROGRANULIN
    GENES["GENES"]
    GENES -->|"activates"| PROGRANULIN
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"activates"| PROGRANULIN
    PARKINSON["PARKINSON"]
    PARKINSON -->|"activates"| PROGRANULIN
    DEMENTIA["DEMENTIA"]
    DEMENTIA -->|"activates"| PROGRANULIN
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"activates"| PROGRANULIN
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"activates"| PROGRANULIN
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    NEUROINFLAMMATION -->|"activates"| PROGRANULIN
    GPNMB["GPNMB"]
    GPNMB -->|"biomarker for"| PROGRANULIN
    CX3CL1["CX3CL1"]
    CX3CL1 -->|"activates"| PROGRANULIN
    style PROGRANULIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (239)

Target	Relation	Type	Str
SMPD1	regulates	gene	0.90
Microglial Inflammatory Response	inhibits	process	0.85
gene- and cell-based interventions	involved_in	biological_process	0.80
Microglia	regulates	cell_type	0.80
Neuroinflammation	activates	disease	0.65
Aging	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
ALS	activates	disease	0.65
Huntington	activates	disease	0.65
Frontotemporal Dementia	activates	disease	0.65
Dementia	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Parkinson	activates	disease	0.65
Prion Disease	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Aging	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
ALS	biomarker_for	disease	0.65
Senescence	biomarker_for	disease	0.65
Fibrosis	biomarker_for	disease	0.65
Dementia	associated_with	disease	0.65
Dementia	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Schizophrenia	biomarker_for	disease	0.65
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.65
Ftd	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Frontotemporal Dementia	biomarker_for	disease	0.65
Dementia	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Ftd	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Frontotemporal Dementia	therapeutic_target	disease	0.65
Neurodegeneration	causes	disease	0.65
Dementia	causes	disease	0.65
Als	causes	disease	0.65
Ftd	causes	disease	0.65
Ms	causes	disease	0.65
Frontotemporal Dementia	causes	disease	0.65
Als	activates	disease	0.65
Als	interacts_with	disease	0.65
Dementia	inhibits	disease	0.65
Alzheimer	expressed_in	disease	0.65
Als	expressed_in	disease	0.65

Incoming (94)

Source	Relation	Type	Str
TREM2	activates	gene	0.60
GPNMB	biomarker_for	gene	0.60
CX3CL1	activates	gene	0.60
CX3CR1	activates	gene	0.60
VIM	activates	gene	0.60
C1Q	biomarker_for	gene	0.60
S100B	biomarker_for	gene	0.60
BDNF	activates	entity	0.60
CXCL10	activates	entity	0.60
FGF21	activates	entity	0.60
FGF23	activates	entity	0.60
FNDC5	activates	entity	0.60
PLAU	activates	entity	0.60
TMEM106B	biomarker_for	gene	0.60
GJA1	activates	gene	0.60
VIMENTIN	activates	gene	0.60
HMGB1	biomarker_for	gene	0.60
APP	biomarker_for	gene	0.60
TGM2	biomarker_for	gene	0.60
TDP-43	activates	gene	0.60
APOE	activates	gene	0.60
SLC1A2	activates	gene	0.60
SMPD1	inhibits	gene	0.60
GAIN	causes	gene	0.60
TDP-43	expressed_in	gene	0.60
TDP-43	therapeutic_target	gene	0.60
GRN	causes	gene	0.60
FUS	expressed_in	gene	0.60
GRN	associated_with	gene	0.60
AQP4	activates	gene	0.60
IRF1	activates	gene	0.60
GRN	transports	gene	0.60
CCR8	transports	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
MICROGLIA	activates	gene	0.60
GENES	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
PARKINSON	activates	gene	0.60
DEMENTIA	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
AGING	activates	gene	0.60
HUNTINGTON	activates	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
AGING	biomarker_for	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	biomarker_for	gene	0.60
NEURODEGENERATIVE DISORDERS	biomarker_for	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
ALS	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PROGRANULIN

Understanding Entity Pages

Summary

Wiki Pages (21)

Progranulin (PGRN) - Biomarker

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Corticobasal Degeneration (CBD)

Therapeutics

Frontotemporal Dementia (FTD) Mechanistic Pathway

Frontotemporal Dementia (FTD)

Microglial Cells — Cell Type Hierarchy

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

oxidative-stress-comparison

ftd-tdp-pathology

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases

rankings

Tau Strain Diversity and Conformational Templating in Tauopathies

Epigenetic Dysregulation Comparison -- AD/PD/ALS/FTD/HD

Neuronal Ceroid Lipofuscinosis (NCL)

Protein Aggregation Comparison in Neurodegeneration