gene 699 words KG: MAOA 2026-03-21
kind:genesection:genesstate:published
Contents

MAOA Gene

🧬 Gene Info
Gene SymbolMAOA
Full NameMonoamine Oxidase A
ChromosomeXp11.23
Protein FamilyMonoamine oxidase family
Protein TypeEnzyme
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight59.7 kDa
PathwaysNeurotoxicity
UniProt ID[P21397](https://www.uniprot.org/uniprot/P21397)
NCBI Gene ID4128
Ensembl IDENSG00000189221
OMIM309850
GeneCardsMAOA
Human Protein AtlasMAOA
Associated DiseasesInflammation, Neurodegeneration, Neuroinflammation, cancer
InteractionsAPP, IL1B, GSK3B, BCL2, CASP3, MAOB
KG Connections119 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

Noradrenergic-Tau Propagation Blockade
Score: 0.51
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (5)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: inhibits
Alzheimer Indonesia
institution · KG edge: therapeutic_target
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: interacts_with
HMOX1 — Heme Oxygenase 1
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

MAOA interacts_with APP
MAOA therapeutic_target BDNF
MAOA therapeutic_target GFAP
MAOA therapeutic_target BAX
MAOA interacts_with IL1B
MAOA interacts_with GSK3B
MAOA therapeutic_target IL1A
MAOA interacts_with BCL2
MAOA interacts_with CASP3
MAOA interacts_with MAOB