gene 2,230 words KG: MYOT
Contents

MYOT Gene

🧬 Gene Info
Gene SymbolMYOT
Chromosome19q13.33
Functionis a gene encoding a Z-disc protein critical for sarcomere organization and maintenance.
Molecular Weight57 kDa
Amino Acids493 aa
Exons13
Pathwaysubiquitin-proteasome
Ensembl IDENSG00000136244
GeneCardsMYOT
Human Protein AtlasMYOT
Associated Diseasesmyofibrillar myopathy
InteractionsAUTOPHAGY, BRCA1, DES, DNAJB6, FLNC, GENES
KG Connections149 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (93)

Purinergic Signaling Polarization Control
Score: 0.71
Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71
Autophagosome Maturation Checkpoint Control
Score: 0.71
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
Orexin-Microglia Modulation Therapy
Score: 0.71
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Lysosomal Enzyme Trafficking Correction
Score: 0.71
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Axonal RNA Transport Reconstitution
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Complement C1q Mimetic Decoy Therapy
Score: 0.69
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Ocular Immune Privilege Extension
Score: 0.69
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
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Related Analyses (27)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived

See Also (15)

ATP P2X3 Receptor Neurons
cell · KG edge: co_discussed
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: co_discussed
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
Genes
index · KG edge: activates
ABCD3 Gene
gene · KG edge: co_discussed

Knowledge Graph (12 edges)

MYOT causes myofibrillar myopathy
MYOT causes Myofibrillar Myopathy
BRCA1 degrades MYOT
DES degrades MYOT
DNAJB6 degrades MYOT
FLNC degrades MYOT
MYOT degrades NBR1
MYOT degrades P62
MYOT degrades SQSTM1
BRCA1 activates MYOT

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