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gene 2,230 words KG: MYOT
Contents

MYOT Gene

🧬 Gene Info
Gene SymbolMYOT
Chromosome19q13.33
Functionis a gene encoding a Z-disc protein critical for sarcomere organization and maintenance.
Molecular Weight57 kDa
Amino Acids493 aa
Exons13
Pathwaysubiquitin-proteasome
Ensembl IDENSG00000136244
GeneCardsMYOT
Human Protein AtlasMYOT
Associated Diseasesmyofibrillar myopathy
InteractionsAUTOPHAGY, BRCA1, DES, DNAJB6, FLNC, GENES
KG Connections149 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (93)

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Score: 0.68Flotillin-1 Stabilization Compounds
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Score: 0.68Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68Osmotic Gradient Restoration via Selective AQP1 Enhancement
Score: 0.68Astrocytic Connexin-43 Upregulation Enhances Neuroprotective
Score: 0.68Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67Complement C1q Subtype Switching
Score: 0.66RNA Granule Nucleation Site Modulation
Score: 0.66Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66Arginine Methylation Enhancement Therapy
Score: 0.65Microbial Inflammasome Priming Prevention
Score: 0.65Nucleolar Stress Response Normalization
Score: 0.65The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65Synthetic Biology Rewiring via Orthogonal Receptors
Score: 0.65Glycine-Rich Domain Competitive Inhibition
Score: 0.64
← Prevpg 3/5Next →

Related Analyses (27)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedEpigenetic reprogramming in aging neurons
neurodegeneration · archivedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived

See Also (15)

ATP P2X3 Receptor Neurons
cell · KG edge: co_discussedAMPK (AMP-Activated Protein Kinase)
entity · KG edge: co_discussedAutophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activatesGenes
index · KG edge: activatesABCD3 Gene
gene · KG edge: co_discussed

Knowledge Graph (12 edges)

MYOT causes myofibrillar myopathy
MYOT causes Myofibrillar Myopathy
BRCA1 degrades MYOT
DES degrades MYOT
DNAJB6 degrades MYOT
FLNC degrades MYOT
MYOT degrades NBR1
MYOT degrades P62
MYOT degrades SQSTM1
BRCA1 activates MYOT

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