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gene 2,633 words KG: RAN
Contents

RAN Gene

🧬 Gene Info
Gene SymbolRAN
Chromosome12q24.1
Amino Acids216 aa
Exons8
PathwaysEpigenetic, Notch, Circadian Rhythm, Tumor Microenvironment, Lipid Metabolism
GeneCardsRAN
Human Protein AtlasRAN
Associated DiseasesAging, Als, Amyotrophic Lateral Sclerosis, Ataxia, Dementia, frontotemporal dementia
Known Drugs/Compoundsmetformin, rapamycin
InteractionsActin, Akt, AKT, ALS, AMPK, AMYOTROPHIC LATERAL SCLEROSIS
KG Connections154 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (44)

Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71Membrane Cholesterol Gradient Modulators
Score: 0.71Axonal RNA Transport Reconstitution
Score: 0.70Lysosomal Positioning Dynamics Modulation
Score: 0.69Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68Flotillin-1 Stabilization Compounds
Score: 0.68Osmotic Gradient Restoration via Selective AQP1 Enhancement
Score: 0.68Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67RNA Granule Nucleation Site Modulation
Score: 0.66Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.62Low Complexity Domain Cross-Linking Inhibition
Score: 0.62LRP1-Dependent Tau Uptake Disruption
Score: 0.60Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56Temporal Decoupling via Circadian Clock Reset
Score: 0.54Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54Blood-Brain Barrier SPM Shuttle System
Score: 0.53
← Prevpg 2/3Next →

Related Analyses (23)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completedAstrocyte Reactivity Subtypes in Neurodegeneration
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · completedPerivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (5)

Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40Validate Mitochondria-Lysosome Contact Site Dysfunction in P
validation · proposed · Score: 0.40Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40

See Also (15)

Synaptic Biomarkers in Neurodegeneration
biomarker · Pages share 33 hypothesesDALY Methodology — Neurodegeneration
disease · Pages share 33 hypothesesLiquid Biopsy in Neurodegeneration
biomarker · Pages share 33 hypothesesNeuroimaging Biomarkers for Neurodegeneration
biomarker · Pages share 33 hypothesesSwedish BioFINDER 2 Study: Biomarkers and Neurodegenera
clinical · Pages share 33 hypotheses

Knowledge Graph (12 edges)

RAN regulates MARK2
RAN regulates C9ORF72
C9ORF72 interacts_with RAN
C9ORF72 associated_with RAN
RAN associated_with GAIN
P62 inhibits RAN
RAN regulates DDX3X
RAN inhibits C9ORF72
NOTCH3 associated_with RAN
EIF2A inhibits RAN

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