gene 1,315 words KG: RPTOR 2026-03-24
kind:genesection:genesstate:published
Contents

RPTOR — Regulatory Associated Protein of MTOR Complex 1

🧬 Gene Info
Gene SymbolRPTOR
Full NameRegulatory Associated Protein of MTOR Complex 1
Chromosome17q25.3.
Functionis an essential scaffolding component of the mTOR Complex 1 (mTORC1), located on chromosome 17q25.
Primary ExpressionHippocampus, Cortex, Cerebellum, Substantia nigra (ubiquitous)
Amino Acids335 aa
Exons30
PathwaysMTOR, mTOR, AMPK, mtor, mTOR pathway
UniProt IDQ8N122
NCBI Gene ID57521
Ensembl IDENSG00000141564
OMIM607592
GeneCardsRPTOR
Human Protein AtlasRPTOR
Symbol [@tramutola2018] RPTOR [@malagelada2010] [@saxton2017] [@tang2019] Full Name [@bov2011] Regulatory Associated Protein of MTOR Complex 1 (Raptor) Chromosome17q25.3
Associated DiseasesAlzheimer's Disease, Parkinson's Disease, Huntington's Disease, Tuberous Sclerosis
Known Drugs/Compoundsrapamycin
InteractionsRB1, EIF2AK3, RIPK1, MAPK14, BECN1, ATF6
KG Connections463 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (22)

APOE-Dependent Autophagy Restoration
Score: 0.61
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66

Related Analyses (10)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · failed

See Also (11)

Alzheimer Indonesia
institution · KG edge: regulates
ATG16L1 - Autophagy Related 16 Like 1
gene · KG edge: interacts_with
ATF6 - Activating Transcription Factor 6
gene · KG edge: interacts_with
APC Gene
gene · KG edge: interacts_with
AMBRA1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

RPTOR interacts_with RB1
RPTOR interacts_with EIF2AK3
RPTOR interacts_with RIPK1
RPTOR interacts_with MAPK14
RPTOR interacts_with BECN1
RPTOR interacts_with ATF6
RPTOR interacts_with DDIT3
RPTOR interacts_with NBR1
RPTOR interacts_with HSP70
RPTOR interacts_with TFE3