gene 702 words KG: RTN3 2026-03-29
kind:genesection:genesstate:published
Contents

RTN3 Gene

🧬 Gene Info
Gene SymbolRTN3
Full NameReticulon 3
AliasesReticulon-3
Chromosome6p22.3
Functionis a member of the reticulon family of membrane proteins primarily localized to the endoplasmic reticulum (ER).
Subcellular Localizationthe endoplasmic reticulum (ER). RTN3 plays critical roles in ER morphology, autophagosome formation, and protein quality
Amino Acids200 aa
PathwaysmTOR, mtor
UniProt IDQ9Y3I0
NCBI Gene ID10318
Ensembl IDENSG00000148681
OMIM604258
GeneCardsRTN3
Human Protein AtlasRTN3
Associated DiseasesAD, ALI, ALS, Alzheimer, Ms
Known Drugs/Compoundsrapamycin
InteractionsSESN2, CANX, MIRO1, EIF2S1, CAT, LC3
KG Connections533 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Phase-Separated Organelle Targeting
Score: 0.52
Autophagosome Maturation Checkpoint Control
Score: 0.49
Stress Granule Phase Separation Modulators
Score: 0.49
RNA Granule Nucleation Site Modulation
Score: 0.48

Related Analyses (4)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (10)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: associated_with
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: interacts_with
ATM Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

RTN3 activates SESN2
RTN3 activates SNCA
RTN3 activates SNCAIP
RTN3 activates SQSTM1
RTN3 activates STING1
RTN3 activates TAX1BP1
RTN3 activates UBIQUITIN
RTN3 activates SNAP29
RTN3 activates STX17
RTN3 activates ULK1