gene 640 words KG: SFN 2026-03-24
kind:genesection:genesstate:published
Contents

SFN Gene

🧬 Gene Info
Gene SymbolSFN
Full NameStratifin (14-3-3 sigma)
Chromosome1p36.22
FunctionSFN encodes 14-3-3 sigma, which has unique functions in neurons
Primary Expressionvarious tissues with notable brain expression in: - Cerebral cortex - Hippocampus - [Cerebellum
PathwaysAutophagy, Cell Cycle, Differentiation, Epigenetic, Nf-Κb
UniProt IDP31947
NCBI Gene ID6278
Ensembl IDENSG00000175793
OMIM605225
GeneCardsSFN
Human Protein AtlasSFN
Associated DiseasesCancer, Lung Cancer, Tumor, neurodegeneration
Known Drugs/CompoundsNFE2L2, quercetin, rapamycin, dasatinib
InteractionsLC3, P62, TRAF6, UBIQUITIN, NLRP3, GSDMD
KG Connections108 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Piezoelectric Nanochannel BBB Disruption
Score: 0.41

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
NRF2 Activator Therapy
idea · KG edge: regulates
NFE2L2 — Nuclear Factor Erythroid 2-Related Factor 2
gene · KG edge: regulates
MYO7A — Myosin VIIa
gene · KG edge: implicated_in

Knowledge Graph (12 edges)

SFN activates NFE2L2
SFN activates LC3
SFN regulates NRF2
SFN activates P62
SFN activates TRAF6
SFN implicated_in MMP9
SFN activates UBIQUITIN
SFN causes ULK1
SFN causes MTOR
SFN regulates IL18