| Gene Symbol | TNF |
| Full Name | Tumor Necrosis Factor |
| Aliases | TNF-α |
| Chromosome | 6p21.33 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | immune cells and endothelial cells](/cell-types/endothelial-cells) - Activates NF-κB and MAPK pathways - [Predominantly pro-survival sign |
| Molecular Weight | 26 kDa |
| Exons | 3 |
| Pathways | NF-κB signaling, NF-κB, MAPK, PI3K |
| Ensembl ID | ENSG00000232890 |
| GeneCards | TNF |
| Human Protein Atlas | TNF |
| TNFR1 (p55) | Ubiquitous, death domain |
| TNFR2 (p75) | Immune cells, tissue-specific |
| Caspase Activation | Apoptosis pathways |
| Associated Diseases | A1_astrocytes, AD, Age-related macular degeneration, Aging, Alopecia Areata, Als |
| Known Drugs/Compounds | ACBA, Adalimumab, Andrographis paniculata, anti-TNF-α monoclonal antibody, BAICALEIN, berberine |
| Interactions | A2M, ABCA1, ABCB1, ABCG1, ABCG2, ACE |
| SciDEX Hypotheses | Temporal Window Specificity |
| KG Connections | 5624 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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