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mechanism 706 words KG: AD
Contents

mitochondrial-dysfunction-ad

⚙ Mechanism Info
NameAD
Key Genes/ProteinsTAU, BETA_AMYLOID, PHOSPHORYLATED_TAU, SOD1
Related Diseasesneurodegeneration, memory_loss, IMMUNE_TOL, DEMENTIA
Related Pathwayscholinergic_transmission, PROTEOME, CHOLINERGIC_TRANSMISSION
Linked Hypotheses71 hypotheses

Knowledge Graph

Related Hypotheses (30)

TREM2-mediated microglial tau clearance enhancement
Score: 0.49TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41Digital Twin-Guided Metabolic Reprogramming
Score: 0.61Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.48

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedAutophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archivedSenolytic therapy for age-related neurodegeneration
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (14)

Tau Consortium
organization · KG edge: associated_withProteome Atlas for Neurodegenerative Diseases
mechanism · KG edge: regulatesAge-Sensitive Cortical Vulnerability in Parkinson's Dis
mechanism · KG edge: associated_withPackard Center for ALS Research
institution · KG edge: implicated_inDementia Australia
institution · KG edge: causes

Knowledge Graph (12 edges)

AD causes neurodegeneration
AD inhibits cholinergic_transmission
AD causes memory_loss
AD associated_with TAU
AD regulates PROTEOME
AD associated_with GLYCOLYTIC_PATHWAY
AD causes IMMUNE_TOL
AD causes DEMENTIA
AD associated_with CHOLINERGIC_TRANSMISSION
TAU associated_with AD
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