gene 1,008 words KG: MLKL
Contents

MLKL Gene

🧬 Gene Info
Gene SymbolMLKL
Chromosome16q23.1
Protein FamilyRHIM domain-containing pseudo-kinase
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight~54 kDa
Amino Acids480 aa
Exons10
PathwaysAkt, Apoptosis, Autophagy, Cell Division, Ferroptosis
UniProt IDQ8TBX5
NCBI Gene ID83568
Ensembl IDENSG00000147854
GeneCardsMLKL
Human Protein AtlasMLKL
Associated DiseasesAls, Alzheimer's disease, autism, DEMYELINATION, disease
Known Drugs/CompoundsHSYA, metformin, METFORMIN, Necrosulfonamide, rapamycin, RAPAMYCIN
InteractionsACSL4, Actin, AD, AIF, AIM2, AKT
KG Connections1241 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (2)

Necroptosis-cGAS Feedforward Loop Converts TDP-43 Pathology
Score: 0.46
Paraneoplastic myelopathies involve CD8+ T cell recognition
Score: 0.45

Knowledge Graph (12 edges)

TFE3 interacts_with MLKL
ATF6 interacts_with MLKL
OPTN interacts_with MLKL
CASP3 interacts_with MLKL
AKT1 interacts_with MLKL
CALCOCO2 interacts_with MLKL
CGAS interacts_with MLKL
CFTR interacts_with MLKL
SQSTM1 interacts_with MLKL
RPS6KB1 interacts_with MLKL

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