protein 1,462 words KG: AKT1
Contents

AKT1 Protein (Protein Kinase B Alpha)

🔬 Protein Info
Gene SymbolAKT1
Protein TypeKinase
Functionis a serine/threonine protein kinase that serves as a central hub in the PI3K/AKT/mTOR signaling pathway, one of the most critical survival and growth signaling cascades in neurons.
Amino Acids480 aa
PathwaysAkt, Apoptosis, Autophagy, Immune Response, Mapk
Ensembl IDENSG00000142208
GeneCardsAKT1
Human Protein AtlasAKT1
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease
Known Drugs/CompoundsAndrographis paniculata, Atbc, berberine, Coumestrol, COUMESTROL, DEP
InteractionsACTB, Actin, AGING, AKT, ALZHEIMER, ALZHEIMER DISEASE
KG Connections1550 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (35)

Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A
Score: 0.67
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.57
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.57
APOE-Dependent Autophagy Restoration
Score: 0.89
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Brain Insulin Resistance with Glucose Transporter Dysfunctio
Score: 0.60
← Prevpg 2/2

Related Analyses (13)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (9)

ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: therapeutic_target
ACTB Gene
gene · KG edge: interacts_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
nct05508789
clinical_trial · Pages share 3 hypotheses
BEACoN Study - Biomarker Exploration in Aging, Cognitio
clinical · Pages share 3 hypotheses

Knowledge Graph (12 edges)

COUMESTROL interacts_with AKT1
OPTN interacts_with AKT1
CASP3 regulates AKT1
AKT1 regulates CALCOCO2
AKT1 regulates CGAS
AKT1 regulates CFTR
AKT1 interacts_with SQSTM1
AKT1 interacts_with RPS6KB1
AKT1 interacts_with GRB2
AKT1 interacts_with RHEB

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