protein 1,089 words KG: CACNA1C 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

Cav1.2 - Voltage-Gated L-Type Calcium Channel (CACNA1C)

🔬 Protein Info
Gene SymbolCACNA1C
AliasesPage for Cav1.2
FunctionCACNA1C encodes the alpha-1C subunit of the L-type voltage-gated calcium channel (Cav1.2), one of the most important calcium channels in neurons and cardiac myocytes
Primary Expressionthe brain, heart, and smooth muscle
Subcellular LocalizationSomatodendritic compartment, dendritic spines, cardiac cells
Molecular Weight250 kDa
PathwaysWnt signaling, oxidative stress response
UniProt IDQ13936
GeneCardsCACNA1C
Human Protein AtlasCACNA1C
N-terminusCytoplasmic
I-II linkerCytoplasmic
III-IV linkerCytoplasmic
C-terminusCytoplasmic
DrugClass
Associated DiseasesAlzheimer, Anxiety, Cancer, Inflammation, Ms, psychiatric disorders
InteractionsCACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I
KG Connections225 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (8)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.47
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.44

Related Analyses (9)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (5)

s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice
falsification · proposed · Score: 0.40
s:** - Compare uptake with/without magnetic particles using
falsification · proposed · Score: 0.40
Blood-Based Biomarker Panel for Early AD Detection
clinical · proposed · Score: 0.40
Blood-Brain Barrier Aging and Neurodegeneration — From Leaka
validation · proposed · Score: 0.40
Vascular Contribution to Alzheimer's Disease — Beyond Amyloi
validation · proposed · Score: 0.40

See Also (6)

Packard Center for ALS Research
institution · KG edge: inhibits
Alzheimer Indonesia
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
CACNA1B Gene
gene · KG edge: associated_with
CACNA1A — Calcium Channel Alpha-1A Subunit
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CACNA1C associated_with PIEZO1
CACNA1C associated_with TRPV4
CACNA1C associated_with OVERVIEW
CACNA1C associated_with CFTR
CACNA1C expressed_in TRPV4
CACNA1C associated_with KCNQ1
CACNA1C associated_with TRPA1
CACNA1C associated_with TRPV1
CACNA1C associated_with TRPM7
CACNA1C associated_with SCN5A