| Gene Symbol | CASP4 |
| Full Name | Caspase-4 |
| Chromosome | 11q22.2 |
| Protein Family | Caspase family, inflammatory caspases (CASP1, CASP4, CASP5) |
| Protein Type | Protease |
| Function | Under conditions of ER stress, such as accumulation of misfolded proteins, CASP4 can be activated directly without inflammasome assembly. |
| Primary Expression | Broad, high in immune cells, CNS neurons and glia |
| Subcellular Localization | Cytoplasm, ER membrane, mitochondria |
| Molecular Weight | 45 kDa (proenzyme), 20+10 kDa (active form) |
| Pathways | Mitochondrial Function, Oxidative Stress, pyroptosis |
| UniProt ID | P49662 |
| Ensembl ID | ENSG00000100994 |
| GeneCards | CASP4 |
| Human Protein Atlas | CASP4 |
| Protein Name | Caspase-4 |
| Associated Diseases | Aging, Als, Alzheimer, Cancer, Dementia, Multiple Sclerosis |
| Interactions | CASP1, Rb, AUTOPHAGY, Caspase, Actin, Ras |
| KG Connections | 163 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |