| Gene Symbol | GRN |
| Aliases | Gene profile: GRN |
| Chromosome | 17q21.31 |
| Protein Family | Granulin family |
| Function | Each granulin domain is approximately 90 amino acids with 12 conserved cysteine residues forming 6 disulfide bonds, creating a compact, stable structure[3]. |
| Primary Expression | Cerebral cortex, Hippocampus, Microglia, Substantia nigra |
| Subcellular Localization | Secreted; also localizes to lysosomes |
| Molecular Weight | ~90 kDa (secreted); 68 kDa (granulin domain) |
| Amino Acids | 593 aa |
| Pathways | Autophagy, Immune Response |
| UniProt ID | P28799 |
| Ensembl ID | ENSG00000030582 |
| GeneCards | GRN |
| Human Protein Atlas | GRN |
| Granulin A | N-terminal granulin |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis |
| Interactions | Actin, AD, ALS, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE |
| SciDEX Hypotheses | GRN/progranulin lysosomal insufficiency across FTD |
| KG Connections | 930 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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