protein 590 words KG: MAPK3 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

MAPK3 Protein (ERK1)

🔬 Protein Info
Gene SymbolMAPK3
Full NameMitogen-Activated Protein Kinase 3
AliasesERK1, p44 MAP Kinase, p44erk
Chromosome16p11.2
Protein FamilyMAP kinase family, CMGC group
Protein TypeKinase
Functionis a serine/threonine protein kinase encoded by the MAPK3 gene.
Subcellular LocalizationCytoplasm, Nucleus
Molecular Weight~43 kDa
Amino Acids379 aa
PathwaysMAPK, mapk
UniProt IDP27361
GeneCardsMAPK3
Human Protein AtlasMAPK3
Protein NameMitogen-Activated Protein Kinase 3
Associated DiseasesALS, Aging, Alzheimer, Atherosclerosis, Cancer
InteractionsNLRP3, ZAP70, TP53, CD19, EEF2, CCL5
KG Connections444 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (13)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (6)

casp3
gene · KG edge: associated_with
BIRC5 (Survivin)
gene · KG edge: therapeutic_target
BCL2 Gene
gene · KG edge: associated_with
ATG5 — Autophagy Related 5
gene · KG edge: activates
AKT1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

MAPK3 therapeutic_target JUN
MAPK3 therapeutic_target PTGS2
MAPK3 therapeutic_target HIF1A
MAPK3 therapeutic_target HSP90AA1
MAPK3 therapeutic_target VEGFA
MAPK3 therapeutic_target MDM2
MAPK3 therapeutic_target AKT1
MAPK3 associated_with MMP9
MAPK3 regulates MAPK1
MAPK3 regulates RELA