protein 590 words KG: MAPK3
Contents

MAPK3 Protein (ERK1)

🔬 Protein Info
Gene SymbolMAPK3
Full NameMitogen-Activated Protein Kinase 3
AliasesPage for MAPK3 Gene
Chromosome16p11.2
Protein FamilyMAP kinase family, CMGC group
Protein TypeKinase
Functionis a serine/threonine protein kinase encoded by the MAPK3 gene.
Subcellular LocalizationCytoplasm, Nucleus
Molecular Weight43 kDa
Amino Acids379 aa
PathwaysMAPK, mapk
UniProt IDP27361
GeneCardsMAPK3
Human Protein AtlasMAPK3
Associated DiseasesAging, Als, Alzheimer, Atherosclerosis, Cancer
InteractionsACTB, Akt, AKT, AKT1, APOPTOSIS, ATG5
KG Connections418 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (13)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57

Related Analyses (8)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (6)

Apoptosis in Neurodegeneration
entity · KG edge: activates
AKT1 Gene
gene · KG edge: activates
ATG5 — Autophagy Related 5
gene · KG edge: activates
BCL2 Gene
gene · KG edge: associated_with
BIRC5 (Survivin)
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

AKT therapeutic_target MAPK3
PI3K therapeutic_target MAPK3
MAPK3 therapeutic_target JUN
MAPK3 therapeutic_target PTGS2
MAPK3 therapeutic_target HIF1A
MAPK3 therapeutic_target HSP90AA1
MAPK3 therapeutic_target VEGFA
MAPK3 therapeutic_target MDM2
MAPK3 therapeutic_target AKT1
MAPK3 associated_with MMP9

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