protein 2,978 words KG: PP2A 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

PP2A Protein

🔬 Protein Info
Gene SymbolPP2A
Full NamePP2A
AliasesPPP2R1A
Chromosome19q13.41
Protein TypeProtein
Subcellular Localization, and biological function 2. In the healthy brain, PP2A continuously
Molecular Weight65 kDa
PathwaysWnt, Notch pathway, mTOR, mtor, Wnt signaling
UniProt IDP30153
NCBI Gene ID5518
Ensembl IDENSG00000114825
OMIM605983
GeneCardsPP2A
Human Protein AtlasPP2A
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, Neurodegeneration, Senescence
Known Drugs/Compoundsdonepezil, resveratrol, rapamycin, metformin, DONEPEZIL, Donepezil
InteractionsGAIN, ERK1, NRF2, KEAP1, PTEN, SQSTM1
KG Connections351 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (16)

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.55
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.50
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.47
VCP-Mediated Autophagy Enhancement
Score: 0.41

Related Analyses (14)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived

See Also (15)

Alzheimer Indonesia
institution · KG edge: activates
ATR Gene
gene · KG edge: activates
AMBRA1 Gene
gene · KG edge: inhibits
AKT1 Gene
gene · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: inhibits

Knowledge Graph (12 edges)

PP2A expressed_in STAR
PP2A associated_with STAR
PP2A inhibits GAIN
PP2A activates ERK1
PP2A activates NRF2
PP2A activates KEAP1
PP2A associated_with AKT
PP2A activates PTEN
PP2A regulates SMAD3
PP2A regulates FOXO1