| Gene Symbol | RIPK3 |
| Function | Necrosome formation: RHIM-RHIM interactions recruit RIPK3 to activated RIPK1; RIPK1 undergoes conformational change exposing its RHIM |
| Primary Expression | Restrictive — immune cells, neurons, some epithelial cells |
| Subcellular Localization | Cytoplasm; translocates to membrane upon activation |
| Molecular Weight | 56.8 kDa (527 amino acids) |
| Amino Acids | 527 aa |
| Pathways | Apoptosis, Autophagy, Dna Methylation, Ferroptosis, Immune Response |
| GeneCards | RIPK3 |
| Human Protein Atlas | RIPK3 |
| N-terminal kinase domain | Residues 1–286 |
| Activation loop | Contains Thr182 |
| RHIM domain | Residues 386–467 |
| C-terminal region | Residues 468–527 |
| Feature | Details |
| Gene | RIPK3 |
| Associated Diseases | AD, ALI, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS |
| Known Drugs/Compounds | RAPAMYCIN, rapamycin, metformin, Adeno-Associated Virus, THSG, Mitochondrial ROS |
| Interactions | DRP1, CHOP, BECN1, PTEN, DDIT3, NBR1 |
| KG Connections | 1470 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |