Complement C1q Blockade for Selective Pruning Prevention
🧪 Overview
A selective C1q inhibitor that only blocks pathological complement tagging while preserving physiological pruning could maintain cognitive synapses through targeting disease-specific conformational changes or co-localization patterns with amyloid.
Debate provenance: derived from debate `sess_sda-2026-04-01-gap-v2-691b42f1` on question: Synaptic pruning by microglia in early AD. Consensus signal: domain_expert, skeptic, synthesizer, theorist discussed the mechanism terms Blockade, C1QA, Complement, Prevention, Pruning, Selective. Novelty signal: skeptic-discussed-with-qualified-concession.
🧬 Mechanism
Auto-built from this analysis's top knowledge-graph edges.
graph TD
C1QA["C1QA"] -->|associated with| synaptic_pruning["synaptic pruning"]
HK2["HK2"] -->|co discussed| C1QA_1["C1QA"]
TREM2["TREM2"] -->|co discussed| C1QA_2["C1QA"]
C1QA_3["C1QA"] -->|co discussed| CX3CR1["CX3CR1"]
C1QA_4["C1QA"] -->|co discussed| ANXA1["ANXA1"]
C1QA_5["C1QA"] -->|co discussed| C1Q["C1Q"]
ANXA1_6["ANXA1"] -->|co discussed| C1QA_7["C1QA"]
C1QA_8["C1QA"] -->|co discussed| HK2_9["HK2"]
C1QA_10["C1QA"] -->|co discussed| TREM2_11["TREM2"]
CX3CR1_12["CX3CR1"] -->|co discussed| C1QA_13["C1QA"]
C1QA_14["C1QA"] -->|co associated with| HK2_15["HK2"]
ANXA1_16["ANXA1"] -->|co associated with| C1QA_17["C1QA"]
C1QA_18["C1QA"] -->|co associated with| CX3CR1_19["CX3CR1"]
style C1QA fill:#ce93d8,stroke:#333,color:#000
style synaptic_pruning fill:#4fc3f7,stroke:#333,color:#000
style HK2 fill:#ce93d8,stroke:#333,color:#000
style C1QA_1 fill:#ce93d8,stroke:#333,color:#000
style TREM2 fill:#ce93d8,stroke:#333,color:#000
style C1QA_2 fill:#ce93d8,stroke:#333,color:#000
style C1QA_3 fill:#ce93d8,stroke:#333,color:#000
style CX3CR1 fill:#ce93d8,stroke:#333,color:#000
style C1QA_4 fill:#ce93d8,stroke:#333,color:#000
style ANXA1 fill:#ce93d8,stroke:#333,color:#000
style C1QA_5 fill:#ce93d8,stroke:#333,color:#000
style C1Q fill:#ce93d8,stroke:#333,color:#000
style ANXA1_6 fill:#ce93d8,stroke:#333,color:#000
style C1QA_7 fill:#ce93d8,stroke:#333,color:#000
style C1QA_8 fill:#ce93d8,stroke:#333,color:#000
style HK2_9 fill:#ce93d8,stroke:#333,color:#000
style C1QA_10 fill:#ce93d8,stroke:#333,color:#000
style TREM2_11 fill:#ce93d8,stroke:#333,color:#000
style CX3CR1_12 fill:#ce93d8,stroke:#333,color:#000
style C1QA_13 fill:#ce93d8,stroke:#333,color:#000
style C1QA_14 fill:#ce93d8,stroke:#333,color:#000
style HK2_15 fill:#ce93d8,stroke:#333,color:#000
style ANXA1_16 fill:#ce93d8,stroke:#333,color:#000
style C1QA_17 fill:#ce93d8,stroke:#333,color:#000
style C1QA_18 fill:#ce93d8,stroke:#333,color:#000
style CX3CR1_19 fill:#ce93d8,stroke:#333,color:#000⚖️ Evidence
No linked papers recorded for this hypothesis yet.
🏥 Translation
🧬 3D Protein Structure — C1QA
💉 Clinical Trials
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for C1QA.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
🏆 Tournament
🏆 Arenas / Elo
📊 Market Indicators
💾 Resource Usage
▸Metadatasource: v1_phase_c_backfill · origin_type: debate_round_mining
| source | v1_phase_c_backfill |
| origin_type | debate_round_mining |
| _schema_version | 1 |