concept

SYNAPTIC PRUNING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNAPTIC PRUNING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

329Connections

4Hypotheses

5Analyses

50Outgoing

50Incoming

11Experiments

3Debates

Summary

SYNAPTIC PRUNING is a concept in neurodegeneration research. Key relationships include: activates, regulates, implicated in. Associated with ALS, Aging, Als. Connected to 140 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	SYNAPTIC PRUNING
Key Genes/Proteins	MICROGLIA, OVERVIEW, INFLAMMATION, COMPLEMENT, NEURODEGENERATIVE DISEASES, NEURON
Related Diseases	Inflammation, Als, Neurodegeneration, Alzheimer
Related Pathways	Complement, Phagocytosis
Linked Hypotheses	5 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    SYNAPTIC_PRUNING["SYNAPTIC PRUNING"]
    SYNAPTIC_PRUNING -->|"activates"| neurodegeneration["neurodegeneration"]
    SYNAPTIC_PRUNING -->|"activates"| Alzheimer["Alzheimer"]
    SYNAPTIC_PRUNING -->|"activates"| Neurodegeneration["Neurodegeneration"]
    SYNAPTIC_PRUNING -->|"activates"| Als["Als"]
    SYNAPTIC_PRUNING -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    SYNAPTIC_PRUNING -->|"activates"| Ms["Ms"]
    SYNAPTIC_PRUNING -->|"regulates"| Autism["Autism"]
    SYNAPTIC_PRUNING -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    complement_activation["complement activation"] -->|"activates"| SYNAPTIC_PRUNING
    microglia["microglia"] -->|"activates"| SYNAPTIC_PRUNING
    PYROPTOSIS["PYROPTOSIS"] -->|"activates"| SYNAPTIC_PRUNING
    MICROGLIA["MICROGLIA"] -->|"activates"| SYNAPTIC_PRUNING
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"activates"| SYNAPTIC_PRUNING
    NEURODEGENERATION["NEURODEGENERATION"] -->|"activates"| SYNAPTIC_PRUNING
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| SYNAPTIC_PRUNING
    P62["P62"] -->|"activates"| SYNAPTIC_PRUNING
    COMPLEMENT["COMPLEMENT"] -->|"inhibits"| SYNAPTIC_PRUNING

Outgoing (203)

Target	Relation	Type	Str
Learning And Memory	regulates	process	0.90
Weakened Synapses	targets	phenotype	0.90
Dysfunctional Synapses	targets	phenotype	0.90
Synaptic Plasticity	regulates	process	0.90
MICROGLIA	activates	gene	0.90
Synapse Formation	associated_with	process	0.85
Neuronal Activity	regulates	process	0.85
Synapse Formation	promotes	process	0.85
Aged Brain	expressed_in	brain_region	0.85
Memory Strength	modulates	phenotype	0.80
Cognitive Decline	correlates_with	phenotype	0.80
neurodegeneration	activates	process	0.75
Inflammation	regulates	disease	0.75
Als	implicated_in	disease	0.75
Neurodegeneration	activates	disease	0.75
Regulated Cell Death	associated_with	process	0.70
OVERVIEW	regulates	gene	0.70
MICROGLIA	regulates	gene	0.70
INFLAMMATION	regulates	gene	0.70
COMPLEMENT	implicated_in	gene	0.70
NEURODEGENERATIVE DISEASES	implicated_in	gene	0.70
NEURON	implicated_in	gene	0.70
Complement	implicated_in	pathway	0.70
PHAGOCYTOSIS	activates	gene	0.70
Phagocytosis	activates	pathway	0.70
NEURON	activates	gene	0.70
Alzheimer	activates	disease	0.65
Als	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Ms	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Epilepsy	associated_with	disease	0.65
Ms	regulates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Autism	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Aging	regulates	disease	0.65
Traumatic Brain Injury	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
ALS	regulates	disease	0.65
Depression	regulates	disease	0.65
Aging	activates	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Parkinson	regulates	disease	0.65
Als	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Aging	associated_with	disease	0.65
Stroke	activates	disease	0.65

Incoming (126)

Source	Relation	Type	Str
Microglia	mediates	cell_type	0.95
MICROGLIA	mediates	cell_type	0.95
Complement	mediates	pathway	0.95
Autophagy	involved_in	process	0.95
MICROGLIA	associated_with	gene	0.90
Complement System	mediates	pathway	0.90
C1Q	involved_in	protein	0.85
C3	involved_in	protein	0.85
CR3	involved_in	receptor	0.85
C1q	involved_in	protein	0.85
CR3	mediates	receptor	0.85
C1Q	mediates	protein	0.85
Complement Inhibition	inhibits	mechanism	0.85
C1q-C3-CR3 Pathway	mediates	pathway	0.85
C1q	mediates	protein	0.80
APOE4	promotes	gene	0.80
TREM2	enhances	gene	0.80
C1Q	enhances	gene	0.80
complement activation	activates	process	0.70
Osteopontin	regulates	protein	0.70
microglia	activates	cell_type	0.70
NEURODEGENERATION	activates	gene	0.70
Pfn1 Expression	prevents	gene	0.70
C1QA	involved_in	gene	0.60
Complement system	activates	pathway	0.60
C3	activates	gene	0.60
CX3CR1	activates	gene	0.60
CD47	activates	gene	0.60
complement cascade	mediates	pathway	0.60
PYROPTOSIS	activates	gene	0.60
MICROGLIA	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
P62	activates	gene	0.60
COMPLEMENT	inhibits	gene	0.60
MICROGLIA	regulates	gene	0.60
TREM2	contributes_to	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
COMPLEMENT	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
C1Q	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
DEPRESSION	regulates	gene	0.60
SYNAPSE	regulates	gene	0.60
CYTOKINES	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
TREM2	therapeutic_target	gene	0.60
AUTOPHAGY	activates	gene	0.60
APOPTOSIS	activates	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TNF-α/IL-1β-Cx43 Hemichannel Axis as Upstream Link Between S	0.663	cell biology	What is the relative contribution of con
Complement-Mediated Synaptic Pruning Dysregulation	0.612	neurodegeneration	Gene expression changes in aging mouse b
Synaptic Pruning Precision Therapy	0.612	Alzheimer's disease	Neuroinflammation and microglial priming
TREM2 Agonism to Redirect Microglia from Synaptic Pruning to	0.521	neurodegeneration	How do ALS-associated OPTN mutations mec

Mentioning Analyses (5)

Scientific analyses that reference this entity

Experiments (11)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Network pharmacology analysis of QTJD active compounds and pathways	exploratory	Mycoplasma pneumoniae pneumoni	0.900	computational network analysis	proposed	N/A
Machine learning-based identification of C1Q hub genes	exploratory	Atherosclerosis	0.900	Human bulk RNA sequencing data	proposed	N/A
scRNA-seq analysis of human atherosclerotic plaques	exploratory	Atherosclerosis	0.900	human atherosclerotic plaque s	proposed	N/A
Sevoflurane-induced neurotoxicity (SIN) model in rats	validation	perioperative neurocognitive d	0.900	rats	proposed	N/A
C1q neutralization experiment	validation	perioperative neurocognitive d	0.900	rats	proposed	N/A
Transcriptomic profiling and differential expression analysis	exploratory	Alzheimer's disease	0.900	1-month-old APP/PS1 mice cereb	proposed	N/A
ox-LDL treatment of RAW264.7 macrophages	exploratory	Atherosclerosis	0.850	RAW264.7 macrophages	proposed	N/A
Gene expression validation in apoE-/- mice	validation	Atherosclerosis	0.850	apoE-/- mice	proposed	N/A
bEV-mediated synaptic pruning via C1q-C3 pathway	exploratory	Alzheimer's disease	0.850	microglia and synapses (in viv	proposed	N/A
Validation of hub genes in ox-LDL treated RAW264.7 macrophages	exploratory	Atherosclerosis	0.800	RAW264.7 macrophages	proposed	N/A
Validation of hub genes in apoE-/- atherosclerotic mice	validation	Atherosclerosis	0.800	apoE-/- mice	proposed	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Perivascular cells induce microglial phagocytic states and synaptic engulfment v [PMID:36747024]	De Schepper S, Ge JZ, Sierksma A, Crowle	Nat Neurosci	2023	2
Prolonged anesthesia induces neuroinflammation and complement-mediated microglia [PMID:36600274]	Xu F, Han L, Wang Y, Deng D, Ding Y, Zha	BMC Med	2023	2
Untitled [PMID:40731189]	Unknown		2025	1
Untitled [PMID:41000995]	Unknown		2025	1
Untitled [PMID:38816415]	Unknown		2024	1
Microglia regulation of synaptic plasticity and learning and memory. [PMID:34472455]	Cornell J, Salinas S, Huang HY, Zhou M	Neural Regen Res	2022	1
Untitled [PMID:34595138]	Unknown		2021	1
Early complement genes are associated with visual system degeneration in multipl [PMID:31289819]	Fitzgerald KC, Kim K, Smith MD, Aston SA	Brain	2019	1
Untitled [PMID:26332001]	Unknown		2016	1
Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721]	["Aranda-Abreu GE", "Rojas-Dur\u00e1n F"	Neurol Int	2026	0
Sustained inhibitory dysfunction in complement component C1qa-deficient mice und [PMID:41544964]	Righes Marafiga J, Vu T, Bowlus J, Barab	Progress in neurobiology	2026	0
Proteomic discoveries in hypermobile Ehlers-Danlos syndrome reveal insights into [PMID:40972649]	Griggs M, Daylor V, Petrucci T, Weintrau	ImmunoHorizons	2025	0
The dopamine analogue CA140 alleviates AD pathology, neuroinflammation, and resc [PMID:39129007]	Chae S, Lee HJ, Lee HE, Kim J, Jeong YJ	J Neuroinflammation	2024	0
The translational gap in neurodegeneration: from animal models to clinical thera [PMID:35168268]	Bhatt D, Bhatt D	Nature Reviews Drug Discovery	2022	0
Single-cell RNA sequencing reveals distinct immunology profiles in human keloid. [PMID:35990663]	["Feng C", "Shan M", "Xia Y", "Zheng Z",	Frontiers in immunology	2022	0
Blood-brain barrier challenges for biologics and gene therapies in neurodegenera [PMID:33986540]	Pardridge WM	Pharmacological Reviews	2021	0
Complement inhibition in neurodegeneration: balancing neuroprotection and immune [PMID:34161779]	Bhatt D, Stevens B, Bhatt D	Nature Reviews Immunology	2021	0
Context-dependent complement activation: pruning is not always pathological [PMID:33657217]	Presumey J, Bhatt D, Bhatt D	Neuron	2021	0
Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. [PMID:32866962]	["Zhang J", "Velmeshev D", "Hashimoto K"	Nature	2020	0
Neurotoxic Reactive Astrocytes Drive Neuronal Death after Retinal Injury. [PMID:32579912]	["Guttenplan K", "Stafford B", "El-Danaf	Cell reports	2020	0

Debates (3)

Multi-agent debates referencing this entity

SYNAPTIC PRUNING

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Corticobasal Syndrome (CBS)

Novel Therapy Index

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

Pathway Diagram

Outgoing (203)

Incoming (126)

Targeting Hypotheses (4)

Mentioning Analyses (5)

What determines the selectivity of complement-mediated synaptic elimination in p

Neuroinflammation and microglial priming in early Alzheimer's Disease