concept

EXTRACELLULAR MATRIX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EXTRACELLULAR MATRIX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

135Connections
1Hypotheses
0Analyses
4Outgoing
50Incoming

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💡 Concept Info
NameEXTRACELLULAR MATRIX
Key Genes/ProteinsTUBB3
Related Diseasescancer, Prostate Cancer, TUMOR
Related PathwaysInvasion
Linked Hypotheses2 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

williams-syndrome

disease · 5022 words

CNTN5 — Contactin 5

gene · 4980 words

Blood-Brain Barrier Dysfunction in Neurodegeneration

mechanism · 4726 words

amyloid-beta-metalloproteinases

mechanism · 4656 words

Pathway Diagram

graph TD
    EXTRACELLULAR_MATRIX["EXTRACELLULAR MATRIX"]
    EXTRACELLULAR_MATRIX -->|"regulates"| Vascular_Homeostasis["Vascular Homeostasis"]
    EXTRACELLULAR_MATRIX -->|"component_of"| Neurovascular_Unit["Neurovascular Unit"]
    EXTRACELLULAR_MATRIX -->|"contributes to"| Vascular_Disease["Vascular Disease"]
    EXTRACELLULAR_MATRIX -->|"regulates"| Vessel_Remodelling["Vessel Remodelling"]
    EXTRACELLULAR_MATRIX -->|"involved_in"| Vascular_Development["Vascular Development"]
    EXTRACELLULAR_MATRIX -->|"involved_in"| Radioresistance["Radioresistance"]
    EXTRACELLULAR_MATRIX -->|"modulates"| Disease_Initiation["Disease Initiation"]
    PERLECAN["PERLECAN"] -->|"component_of"| EXTRACELLULAR_MATRIX
    LOXL3["LOXL3"] -->|"involved_in"| EXTRACELLULAR_MATRIX
    LOX_FAMILY["LOX FAMILY"] -->|"regulates"| EXTRACELLULAR_MATRIX
    ECM_Producing_Cells["ECM-Producing Cells"] -->|"involved_in"| EXTRACELLULAR_MATRIX
    LOX["LOX"] -->|"involved_in"| EXTRACELLULAR_MATRIX
    Lysyl_Oxidase["Lysyl Oxidase"] -->|"modulates"| EXTRACELLULAR_MATRIX
    JUN["JUN"] -->|"inhibits"| EXTRACELLULAR_MATRIX
    HAPLN4["HAPLN4"] -->|"participates in"| EXTRACELLULAR_MATRIX

Outgoing (30)

TargetRelationTypeStr
CELL MIGRATIONactivatesconcept0.50
CENTRAL NERVOUS SYSTEMexpressed_inconcept0.50
CHRONIC INFLAMMATIONinteracts_withconcept0.50
WNT SIGNALINGassociated_withconcept0.50

Incoming (105)

SourceRelationTypeStr
cancerregulatesdisease0.50
HSPG2regulatesconcept0.50
Prostate Cancerregulatesdisease0.50
HSPG2associated_withconcept0.50
canceractivatesdisease0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Extracellular Matrix Stiffness Modulation 0.427 neurodegeneration Microglia-astrocyte crosstalk amplificat

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Brain Capillary Ion Channels: Physiology and Channelopathies. [PMID:40748720] Harraz OF, Hashad AM Physiology (Bethesda) 2026 1
Stiffness sensing via Piezo1 enhances macrophage efferocytosis and promotes the [PMID:38838160] Wang Y, Wang J, Zhang J, Wang Y, Wang Y, Sci Adv 2024 1
Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central [PMID:37532007] Zong B, Yu F, Zhang X, Pang Y, Zhao W, S Ageing Res Rev 2023 1
Targeting extracellular matrix stiffness and mechanotransducers to improve cance [PMID:35331296] Jiang Y, Zhang H, Wang J, Liu Y, Luo T, J Hematol Oncol 2022 1
Mechanically activated ion channel Piezo1 modulates macrophage polarization and [PMID:34059671] Atcha H, Jairaman A, Holt JR, Meli VS, N Nat Commun 2021 1
Excessive compression induces cartilage endplate degeneration via the Piezo1/NAT [PMID:41175920] Sun H, Wu Z, Zhang Y, Liu C, Gao D et al Osteoarthritis Cartilage 2026 0
Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolis [PMID:41486513] Ma J, Xie N, Wang Z, Liang X, Han Y et a Adv Sci (Weinh) 2026 0
Insights into the role of the mechanosensitive Piezo1 channel and signaling mech [PMID:41544798] Zhang M, Ge Y, Wang Z, Li H, Wang G et a Neurosci Biobehav Rev 2026 0
Long-range chemical signalling in vivo is regulated by mechanical signals. [PMID:41555045] Pillai EK, Mukherjee S, Gampl N, McGinn Nat Mater 2026 0
The Glymphatic System and Meningeal Lymphatics: Current Understandings and Futur [PMID:41930354] Sun H, Fan H, Zhou Y, Zhu H, Chen Y et a MedComm (2020) 2026 0
Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for All [PMID:41933910] Wolters A, Signorelli L, Herff C, Gimple Adv Sci (Weinh) 2026 0
A 3D-Printed Pulsatile Shear Stress Platform for Studying Endothelial Cell Mecha [PMID:41949555] Romanov V, Li JV, Zhao F, Cheng D, Marti Anal Chem 2026 0
Piezo channels in tumors. [PMID:41964669] Zhang W, Dai L, Shi H J Cancer Res Clin Oncol 2026 0
Direct pharmacological targeting of Piezo1 by Paeoniflorin: a novel therapeutic [PMID:40653265] ["Li R", "Xia J", "Shi C", "Zhang K", "Q Journal of advanced research 2026 0
Piezo1 is a pathogenic gene and therapeutic target for neurological diseases. [PMID:40276938] Wang H, Gou Z, Chen S, Lu L The International journal of n 2026 0
Mechanosensitive channel Piezo1 in calcium dynamics: structure, function, and em [PMID:41195420] Liu Y, Xu YQ, Long YY, Xiao H, Ma YY, Li Frontiers in molecular bioscie 2025 0
PIEZO1: a mechanosensitive ion channel in the pathogenesis and pharmacotherapy o [PMID:41051683] Gupta T, Singh TG, Singh R Molecular biology reports 2025 0
Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion [PMID:38744281] Zhang J, Li J, Hou Y, Lin Y, Zhao H, Shi Cell 2024 0
The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing nov [PMID:35236990] ["Costello S", "Shoemaker S", "Hobbs H", Nature structural & molecular 2022 0
Activation of Piezo1 contributes to matrix stiffness-induced angiogenesis in hep [PMID:36181398] Li M, Zhang X, Wang M, Wang Y, Qian J, X Cancer communications (London, 2022 0