protein

ATP1A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATP1A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections
0Hypotheses
0Analyses
23Outgoing
6Incoming

Summary

ATP1A1 is a protein involved in neurodegeneration research. Key relationships include: associated with, contributes to, regulates. Associated with Aging, Als, Cardiovascular. Connected to 25 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolATP1A1
Full NameATPase Na+/K+ Transporting Subunit Alpha 1
Chromosome1p13.1
FunctionATP1A1 encodes the alpha-1 subunit of Na+/K+ ATPase.
Primary Expressionmost cell types including neurons, astrocytes, and oligodendrocytes
Molecular Weight112 kDa
Amino Acids1000 aa
PathwaysApoptosis, Immune Response
UniProt ID[P05023](https://www.uniprot.org/uniprotkb/P05023/entry)
GeneCardsATP1A1
Human Protein AtlasATP1A1
Associated DiseasesAging, Als, Cardiovascular, Ms
KG Connections29 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

ATP1A1 Gene

gene · 607 words

Gene Page: ANK2 (Ankyrin-2)

gene · 2116 words

ATP1A2 Gene

gene · 1883 words

ATP1B2 Gene

gene · 1761 words

atp1b3

gene · 1714 words

ATP1B1 Gene

gene · 1564 words

Pathway Diagram

graph TD
    ATP1A1["<b>ATP1A1</b>"]
    Ms{"Ms"}
    ATP1A1 -->|"regulates"| Ms
    Als{"Als"}
    ATP1A1 -->|"associated with"| Als
    Aging{"Aging"}
    ATP1A1 -->|"associated with"| Aging
    ATP1A1 -->|"associated with"| Ms
    Cardiovascular{"Cardiovascular"}
    ATP1A1 -->|"associated with"| Cardiovascular
    RAB11B["RAB11B"]
    ATP1A1 -->|"regulates"| RAB11B
    AMBRA1["AMBRA1"]
    ATP1A1 -->|"regulates"| AMBRA1
    SORT1["SORT1"]
    ATP1A1 -->|"regulates"| SORT1
    APOPTOSIS["APOPTOSIS"]
    ATP1A1 -->|"regulates"| APOPTOSIS
    Apoptosis(["Apoptosis"])
    ATP1A1 -->|"regulates"| Apoptosis
    Immune_Response(["Immune Response"])
    ATP1A1 -->|"regulates"| Immune_Response
    PRDX6["PRDX6"]
    ATP1A1 -->|"contributes to"| PRDX6
    AGING["AGING"]
    AGING -->|"associated with"| ATP1A1
    TSC1["TSC1"]
    TSC1 -->|"contributes to"| ATP1A1
    CREB3["CREB3"]
    CREB3 -->|"contributes to"| ATP1A1
    style ATP1A1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (24)

TargetRelationTypeStr
ds-83b31ef18d49provides_data_fordataset1.00
Msregulatesdisease0.65
Alsassociated_withdisease0.65
Agingassociated_withdisease0.65
Msassociated_withdisease0.65

Incoming (6)

SourceRelationTypeStr
ds-83b31ef18d49data_indataset1.00
APOE4downregulatesgene0.90
TSC1contributes_togene0.60
CREB3contributes_togene0.60
AGINGassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found