Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ATP1A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
ATP1A1 is a protein involved in neurodegeneration research. Key relationships include: associated with, contributes to, regulates. Associated with Aging, Als, Cardiovascular. Connected to 25 entities in the SciDEX knowledge graph.
| Gene Symbol | ATP1A1 |
| Full Name | ATPase Na+/K+ Transporting Subunit Alpha 1 |
| Chromosome | 1p13.1 |
| Function | ATP1A1 encodes the alpha-1 subunit of Na+/K+ ATPase. |
| Primary Expression | most cell types including neurons, astrocytes, and oligodendrocytes |
| Molecular Weight | 112 kDa |
| Amino Acids | 1000 aa |
| Pathways | Apoptosis, Immune Response |
| UniProt ID | [P05023](https://www.uniprot.org/uniprotkb/P05023/entry) |
| GeneCards | ATP1A1 |
| Human Protein Atlas | ATP1A1 |
| Associated Diseases | Aging, Als, Cardiovascular, Ms |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ATP1A1["<b>ATP1A1</b>"]
Ms{"Ms"}
ATP1A1 -->|"regulates"| Ms
Als{"Als"}
ATP1A1 -->|"associated with"| Als
Aging{"Aging"}
ATP1A1 -->|"associated with"| Aging
ATP1A1 -->|"associated with"| Ms
Cardiovascular{"Cardiovascular"}
ATP1A1 -->|"associated with"| Cardiovascular
RAB11B["RAB11B"]
ATP1A1 -->|"regulates"| RAB11B
AMBRA1["AMBRA1"]
ATP1A1 -->|"regulates"| AMBRA1
SORT1["SORT1"]
ATP1A1 -->|"regulates"| SORT1
APOPTOSIS["APOPTOSIS"]
ATP1A1 -->|"regulates"| APOPTOSIS
Apoptosis(["Apoptosis"])
ATP1A1 -->|"regulates"| Apoptosis
Immune_Response(["Immune Response"])
ATP1A1 -->|"regulates"| Immune_Response
PRDX6["PRDX6"]
ATP1A1 -->|"contributes to"| PRDX6
AGING["AGING"]
AGING -->|"associated with"| ATP1A1
TSC1["TSC1"]
TSC1 -->|"contributes to"| ATP1A1
CREB3["CREB3"]
CREB3 -->|"contributes to"| ATP1A1
style ATP1A1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Ms | regulates | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Cardiovascular | associated_with | disease | 0.65 |
| RAB11B | regulates | gene | 0.60 |
| AMBRA1 | regulates | gene | 0.60 |
| SORT1 | regulates | gene | 0.60 |
| PRDX6 | contributes_to | gene | 0.60 |
| YWHAZ | contributes_to | gene | 0.60 |
| MAPK14 | contributes_to | gene | 0.60 |
| LMNA | contributes_to | gene | 0.60 |
| RAGE | associated_with | gene | 0.60 |
| APOPTOSIS | regulates | gene | 0.60 |
| Apoptosis | regulates | pathway | 0.60 |
| Immune Response | regulates | pathway | 0.60 |
| HSPB1 | contributes_to | gene | 0.60 |
| OXIDATIVE STRESS | associated_with | gene | 0.60 |
| Notch | associated_with | pathway | 0.60 |
| Mapk | contributes_to | pathway | 0.60 |
| Oxidative Stress | associated_with | pathway | 0.60 |
| benchmark_ot_ad_answer_key:ATP1A1 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| APOE4 | downregulates | gene | 0.90 |
| TSC1 | contributes_to | gene | 0.60 |
| CREB3 | contributes_to | gene | 0.60 |
| AGING | associated_with | gene | 0.60 |
| benchmark_ot_ad_answer_key:ATP1A1 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||