gene

YWHAZ

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about YWHAZ: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

150Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

YWHAZ is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, contributes to. Associated with Aging, Als, Alzheimer. Connected to 52 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	YWHAZ
Full Name	Tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein Zeta/Delta
Chromosome	8q23.1
Function	YWHAZ encodes 14-3-3 zeta/delta, a versatile adaptor protein
Primary Expression	cancers and promotes tumor progression
Pathways	MAPK, PI3K
UniProt ID	P63169
NCBI Gene ID	7534
Ensembl ID	ENSG00000164924
OMIM	603551
GeneCards	YWHAZ
Human Protein Atlas	YWHAZ
Associated Diseases	Aging, Als, Cancer, Carcinoma, Cardiovascular, Ms
Interactions	ACTB, ACTG1, AND, ATP5A1, AXIN1, CCND1
KG Connections	150 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: YWHAZ — AlphaFold P63169 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

YWHAZ Gene

gene · 2161 words

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Pathway Diagram

graph TD
    YWHAZ["<b>YWHAZ</b>"]
    Parkinson{"Parkinson"}
    YWHAZ -->|"associated with"| Parkinson
    YWHAZ -->|"therapeutic target"| Parkinson
    Alzheimer{"Alzheimer"}
    YWHAZ -->|"therapeutic target"| Alzheimer
    Huntington{"Huntington"}
    YWHAZ -->|"therapeutic target"| Huntington
    Ms{"Ms"}
    YWHAZ -->|"therapeutic target"| Ms
    Carcinoma{"Carcinoma"}
    YWHAZ -->|"associated with"| Carcinoma
    Cancer{"Cancer"}
    YWHAZ -->|"associated with"| Cancer
    Tumor{"Tumor"}
    YWHAZ -->|"associated with"| Tumor
    Als{"Als"}
    YWHAZ -->|"associated with"| Als
    Aging{"Aging"}
    YWHAZ -->|"associated with"| Aging
    YWHAZ -->|"associated with"| Ms
    Cardiovascular{"Cardiovascular"}
    YWHAZ -->|"associated with"| Cardiovascular
    CCT2["CCT2"]
    CCT2 -->|"interacts with"| YWHAZ
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"therapeutic target"| YWHAZ
    GFAP["GFAP"]
    GFAP -->|"interacts with"| YWHAZ
    GRIA1["GRIA1"]
    GRIA1 -->|"interacts with"| YWHAZ
    SNAP25["SNAP25"]
    SNAP25 -->|"interacts with"| YWHAZ
    ACTG1["ACTG1"]
    ACTG1 -->|"interacts with"| YWHAZ
    SNCA["SNCA"]
    SNCA -->|"interacts with"| YWHAZ
    GAPDH["GAPDH"]
    GAPDH -->|"interacts with"| YWHAZ
    MAPK1["MAPK1"]
    MAPK1 -->|"interacts with"| YWHAZ
    PSMA3["PSMA3"]
    PSMA3 -->|"interacts with"| YWHAZ
    SOX2["SOX2"]
    SOX2 -->|"interacts with"| YWHAZ
    AGING["AGING"]
    AGING -->|"associated with"| YWHAZ
    style YWHAZ fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (83)

Target	Relation	Type	Str
Parkinson	associated_with	disease	0.70
Ms	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Als	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
ALS	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Huntington	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Prion	therapeutic_target	disease	0.65
ATP5A1	interacts_with	gene	0.60
SOD1	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
MYC	activates	gene	0.60
STAT3	activates	gene	0.60
EGR1	activates	gene	0.60
TBP	activates	gene	0.60
RELA	activates	gene	0.60
RHEB	activates	gene	0.60
SPI1	activates	gene	0.60
HNF4A	activates	gene	0.60
AXIN1	activates	gene	0.60
CANCER	associated_with	gene	0.60
Glycolysis	associated_with	pathway	0.60
Amyloid	regulates	pathway	0.60
HSP90AB1	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
CDC42	interacts_with	gene	0.60
LMNA	contributes_to	gene	0.60
RAGE	associated_with	gene	0.60
ALZHEIMER	regulates	gene	0.60
MYH9	activates	gene	0.60
CCND1	activates	gene	0.60
MIRNAS	activates	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
MAPK14	contributes_to	gene	0.60
MAPK signaling	participates_in	pathway	0.60
SOCS3	activates	gene	0.60
HSPB1	contributes_to	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
Notch	associated_with	pathway	0.60
Mapk	contributes_to	pathway	0.60
VDAC1	associated_with	gene	0.60

Incoming (67)

Source	Relation	Type	Str
TBP	activates	gene	0.60
CAV1	expressed_in	gene	0.60
CYCS	expressed_in	gene	0.60
ENO1	expressed_in	gene	0.60
HSP90AB1	expressed_in	gene	0.60
HSPA4	expressed_in	gene	0.60
ITGAM	expressed_in	gene	0.60
NFKBIA	expressed_in	gene	0.60
PPARG	expressed_in	gene	0.60
RELA	expressed_in	gene	0.60
RHOA	expressed_in	gene	0.60
SOD1	expressed_in	gene	0.60
TP53	expressed_in	gene	0.60
VDAC1	expressed_in	gene	0.60
MYO1C	activates	gene	0.60
AGING	associated_with	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
HUNTINGTON	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
PSMD14	interacts_with	gene	0.60
FN1	interacts_with	gene	0.60
MICRORNAS	regulates	gene	0.60
AMYLOID	regulates	gene	0.60
SOD1	interacts_with	gene	0.60
CDC42	interacts_with	gene	0.60
HSP90AB1	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
ATP5A1	interacts_with	gene	0.60
AXIN1	activates	gene	0.60
STAT3	activates	gene	0.60
RHEB	activates	gene	0.60
EGR1	activates	gene	0.60
HNF4A	activates	gene	0.60
MYC	activates	gene	0.60
AND	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
ANXA5	expressed_in	gene	0.60
CCND1	expressed_in	gene	0.60
SLC16A3	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
MYH9	activates	gene	0.60
HUB GENES	regulates	gene	0.60
MIRNAS	activates	gene	0.60
MIR-155	activates	gene	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
CCND1	activates	gene	0.60
GENES	activates	gene	0.60
TSC1	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity