gene

DNAJC13

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNAJC13: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections

0Hypotheses

0Analyses

34Outgoing

11Incoming

Summary

Gene: DNAJC13 — DnaJ Heat Shock Protein Family Member C13 (RME-8)

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🧬 Gene Info

Gene Symbol	DNAJC13
Full Name	DnaJ Heat Shock Protein Family Member C13
Aliases	RME-8
Chromosome	3q22.1
Protein Type	Chaperone
Function	is a co-chaperone protein primarily localized to endosomal membranes where it functions as a critical regulator of endosomal trafficking and protein quality control.
Primary Expression	neurons throughout the brain, particularly in dopaminergic neurons of the substantia nigra pars compacta
Subcellular Localization	endosomal membranes where it functions as a critical regulator of endosomal trafficking and protein quality control. Ori
Molecular Weight	280 kDa
Amino Acids	558 aa
Exons	33
Pathways	mTOR, mtor
GeneCards	DNAJC13
Human Protein Atlas	DNAJC13
Variant	Inheritance
Associated Diseases	Als, Alzheimer, Parkinson, Parkinson's disease
KG Connections	45 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DNAJC13["<b>DNAJC13</b>"]
    DNA["DNA"]
    DNAJC13 -->|"regulates"| DNA
    neurodegeneration["neurodegeneration"]
    DNAJC13 -->|"implicated in"| neurodegeneration
    DNA -->|"regulates"| DNAJC13
    LYSOSOME["LYSOSOME"]
    LYSOSOME -->|"associated with"| DNAJC13
    AND["AND"]
    AND -->|"regulates"| DNAJC13
    style DNAJC13 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (34)

Target	Relation	Type	Str
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
FBXO7	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
VPS13C	associated_with	gene	0.60
DNAJC6	associated_with	gene	0.60
ATP13A2	associated_with	gene	0.60
PLA2G6	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
ATP1A3	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
GBA	associated_with	gene	0.60
GCH1	associated_with	gene	0.60
RAB39B	associated_with	gene	0.60
GABARAP	regulates	gene	0.60
LC3	regulates	gene	0.60
neurodegeneration	regulates	disease	0.60
GBA1	associated_with	gene	0.60
PARK7	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
VPS35	associated_with	gene	0.60
DNA	regulates	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
Parkinson's disease	associated_with	disease	0.60
HSC70	regulates	gene	0.60
neurons	expressed_in	cell_type	0.60
oxidative stress response	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
MAP1LC3	regulates	gene	0.60
Parkinson's disease	regulates	disease	0.60

Incoming (11)

Source	Relation	Type	Str
GCH1	associated_with	gene	0.60
VPS35	associated_with	gene	0.60
GBA1	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
PARK7	associated_with	gene	0.60
ATP13A2	associated_with	gene	0.60
ATXN2	associated_with	gene	0.60
ATP1A3	associated_with	gene	0.60
DNA	regulates	gene	0.60
LYSOSOME	associated_with	gene	0.60
ATG	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DNAJC13

Understanding Entity Pages

Summary

Wiki Pages (21)

DNAJC13 — DnaJ Heat Shock Protein Family Member C13

Synaptic Vesicle Trafficking in Parkinson's Disease

Gene-Mechanism-Therapy Causal Chains

proteasome-ubiquitin-system-dysfunction-parkinsons

MSA Genetics and Risk Factors

Lysosomal Dysfunction in Progressive Supranuclear Palsy

Parkinson's Disease Mechanisms

ER-Golgi Secretory Pathway Dysfunction Hypothesis in Parkinson's Disease

Chaperone-Mediated Proteostasis Disease Comparison

Mitochondrial Dysfunction in PD

SYNJ1 — Synaptojanin 1

RAB39B Gene

DNAJB5 (DnaJ Heat Shock Protein Family Member B5)

Parkinson's Canada

Autophagy-Lysosomal Dysfunction in Neurodegenerative Diseases

GIGYF2 — GRB10 Interacting GYF Protein 2

FAM171A2 Gene — Neuronal Receptor for Alpha-Synuclein

protein-trafficking-pathways

BLAAC PD - Black and African Americans Connections to PD (NCT06719583)