gene

AXIN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AXIN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

237Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

AXIN2 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, regulates. Associated with ALS, Als, Cancer. Connected to 135 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	AXIN2
Chromosome	17q24.1
Protein Type	Gene
Function	is a critical negative regulator of the Wnt/beta-catenin signaling pathway.
Primary Expression	neural stem cells (NSCs) in the adult subventricular zone (SVZ) and dentate gyrus subgranular zone (SGZ):
Molecular Weight	88 kDa
Amino Acids	778 aa
Pathways	Wnt, Wnt signaling, Wnt pathway
UniProt ID	Q9Y2T1
NCBI Gene ID	8313
Ensembl ID	ENSG00000168646
GeneCards	AXIN2
Human Protein Atlas	AXIN2
Associated Diseases	Cancer, Carcinoma
Known Drugs/Compounds	rapamycin
Interactions	AMPK, ATG, BECN1, CCND1, CYCLIN D1, FAM83A
KG Connections	237 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: AXIN2 — AlphaFold Q9Y2T1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    AXIN2["AXIN2 Scaffold"] -->|"Forms complex with"| APC["APC Protein"]
    AXIN2 -->|"Regulates"| AXIN1["AXIN1 Paralog"]
    APC -->|"Promotes"| BetaCat["beta-Catenin Degradation"]
    AXIN2 -->|"Inhibits"| Wnt["Wnt / beta-Catenin Signaling"]
    Wnt -->|"Drives"| CD44["CD44 Expression"]
    Wnt -->|"Drives"| ALDH1A1["ALDH1A1 Stem Marker"]
    AXIN2 -->|"Interacts with"| AMPK["AMPK Kinase"]
    AXIN2 -->|"Regulates"| Autophagy["Autophagy via BECN1"]
    AXIN2 -->|"Modulates"| ATF3["ATF3 Stress Response"]
    AXIN2 -.Tumor suppressor.-> Cancer["Cancer Pathways"]
    AXIN2 -.Therapeutic target.-> ALS["ALS Research"]

Outgoing (156)

Target	Relation	Type	Str
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Tumor	regulates	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Cancer	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Carcinoma	associated_with	disease	0.65
Tumor	activates	disease	0.65
ALS	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
ALS	activates	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
CBP	regulates	gene	0.60
CDH5	regulates	gene	0.60
CTNNB1	regulates	gene	0.60
EP300	regulates	gene	0.60
MUC1	regulates	gene	0.60
MUC16	regulates	gene	0.60
BRG1	regulates	gene	0.60
MYC	targets	gene	0.60
NEUROD1	targets	gene	0.60
NOTCH2	targets	gene	0.60
SNAI1	targets	gene	0.60
TERT	targets	gene	0.60
OPA1	expressed_in	gene	0.60
SMARCA4	regulates	gene	0.60
AMPK	associated_with	gene	0.60
Wnt	therapeutic_target	pathway	0.60
Epigenetic	regulates	pathway	0.60
Notch	therapeutic_target	pathway	0.60
WNT	expressed_in	gene	0.60
Wnt	expressed_in	pathway	0.60
Neuron	inhibits	cell_type	0.60
TNFRSF19	targets	gene	0.60

Incoming (81)

Source	Relation	Type	Str
TCF4	associated_with	gene	0.60
MYC	associated_with	gene	0.60
LC3	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
CTNNB1	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
CLDN1	therapeutic_target	gene	0.60
AXIN1	regulates	gene	0.60
CD44	therapeutic_target	gene	0.60
FGF18	therapeutic_target	gene	0.60
PPARD	therapeutic_target	gene	0.60
APC	regulates	gene	0.60
CREBBP	regulates	gene	0.60
APC	activates	entity	0.60
MIR454	associated_with	gene	0.60
CCND1	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
CDH1	regulates	gene	0.60
GENES	therapeutic_target	gene	0.60
RNA	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
ATG	associated_with	gene	0.60
CSNK1A1	associated_with	gene	0.60
GFP	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
ATG	activates	gene	0.60
rapamycin	targets	drug	0.60
ALDH1A1	targets	gene	0.60
ABCB1	targets	gene	0.60
P62	activates	gene	0.60
GSK3B	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
MYC	regulates	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
AXIN	associated_with	gene	0.60
AMPK	activates	entity	0.60
SQSTM1	associated_with	gene	0.60
LEF1	therapeutic_target	gene	0.60
FGF20	therapeutic_target	gene	0.60
BRG1	regulates	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	regulates	gene	0.60
CTNNB1	regulates	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AXIN2 in their description or question text

No additional research found