gene

AXIN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AXIN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

256Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

AXIN2 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, regulates. Associated with ALS, Als, Cancer. Connected to 135 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	AXIN2
Full Name	AXIN2
Chromosome	17q24.1
Protein Type	Gene
Function	is a critical negative regulator of the Wnt/beta-catenin signaling pathway.
Primary Expression	neural stem cells (NSCs) in the adult subventricular zone (SVZ) and dentate gyrus subgranular zone (SGZ):
Molecular Weight	88 kDa
Amino Acids	778 aa
Pathways	Wnt, Wnt signaling, Wnt pathway
UniProt ID	Q9Y2T1
NCBI Gene ID	8313
Ensembl ID	ENSG00000168646
GeneCards	AXIN2
Human Protein Atlas	AXIN2
Associated Diseases	Cancer, Carcinoma
Known Drugs/Compounds	rapamycin
Interactions	P62, MYC, MKI67, WIF1, AND, CCND1
KG Connections	256 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: AXIN2 — AlphaFold Q9Y2T1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    AXIN2["AXIN2 Scaffold"] -->|"Forms complex with"| APC["APC Protein"]
    AXIN2 -->|"Regulates"| AXIN1["AXIN1 Paralog"]
    APC -->|"Promotes"| BetaCat["beta-Catenin Degradation"]
    AXIN2 -->|"Inhibits"| Wnt["Wnt / beta-Catenin Signaling"]
    Wnt -->|"Drives"| CD44["CD44 Expression"]
    Wnt -->|"Drives"| ALDH1A1["ALDH1A1 Stem Marker"]
    AXIN2 -->|"Interacts with"| AMPK["AMPK Kinase"]
    AXIN2 -->|"Regulates"| Autophagy["Autophagy via BECN1"]
    AXIN2 -->|"Modulates"| ATF3["ATF3 Stress Response"]
    AXIN2 -.Tumor suppressor.-> Cancer["Cancer Pathways"]
    AXIN2 -.Therapeutic target.-> ALS["ALS Research"]

Outgoing (173)

Target	Relation	Type	Str
Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Tumor	activates	disease	0.65
Als	activates	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Tumor	regulates	disease	0.65
Carcinoma	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
ALS	activates	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
GAPDH	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
GSK3B	associated_with	gene	0.60
APC	associated_with	gene	0.60
P62	activates	gene	0.60
MTOR	associated_with	gene	0.60
CTNNB1	associated_with	gene	0.60
MYC	associated_with	gene	0.60
TCF4	associated_with	gene	0.60
LC3	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
CD44	therapeutic_target	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
FGF18	therapeutic_target	gene	0.60
ATF3	therapeutic_target	gene	0.60
IL10	therapeutic_target	gene	0.60
DKK1	therapeutic_target	gene	0.60
PPARD	therapeutic_target	gene	0.60
CLDN1	therapeutic_target	gene	0.60
APC	regulates	gene	0.60

Incoming (83)

Source	Relation	Type	Str
TCF4	associated_with	gene	0.60
MYC	associated_with	gene	0.60
LC3	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
CTNNB1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
FGF20	therapeutic_target	gene	0.60
BRG1	regulates	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	regulates	gene	0.60
CTNNB1	regulates	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
FOXM1	regulates	gene	0.60
LEF1	therapeutic_target	gene	0.60
SMARCA4	regulates	gene	0.60
TERT	therapeutic_target	gene	0.60
FZD7	therapeutic_target	gene	0.60
JAG1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
APC	associated_with	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
CLDN1	therapeutic_target	gene	0.60
AXIN1	regulates	gene	0.60
CD44	therapeutic_target	gene	0.60
FGF18	therapeutic_target	gene	0.60
PPARD	therapeutic_target	gene	0.60
APC	regulates	gene	0.60
CREBBP	regulates	gene	0.60
P62	activates	gene	0.60
GSK3B	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
IL10	therapeutic_target	gene	0.60
MYC	regulates	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
APC	activates	entity	0.60
CACNA1G	expressed_in	gene	0.60
LEF1	expressed_in	gene	0.60
ABCB1	targets	gene	0.60
ALDH1A1	targets	gene	0.60
ATF3	targets	gene	0.60
MAP1LC3	associated_with	gene	0.60
CDH1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

AXIN2

Understanding Entity Pages

Summary

Wiki Pages (21)

AXIN2 Gene

WNT7A Gene

Wnt-Beta-Catenin Signaling Dysfunction Hypothesis in Parkinson's Disease

Wnt Signaling in Neurodegeneration

DVL3 — Dishevelled Segment Polarity Protein 3

FZD8 Gene

LEF1

FZD8 Protein

CTNNB1 — Catenin Beta 1

Wnt Signaling in Parkinson's Disease

WNT3 Gene

AXIN2 Protein

WNT10A Gene

WNT7B Gene - Wnt Family Member 7B

CHD8 Gene

beta-catenin-protein

AXIN1 Protein

WNT8A Gene

FZD9 Protein