concept

MUC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MUC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

39Connections

1Hypotheses

0Analyses

22Outgoing

17Incoming

0Experiments

0Debates

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💡 Concept Info

Name	MUC1
Key Genes/Proteins	APC, AQP5, AXIN1, AXIN2, BRG1, CBP
Related Diseases	cancer
Related Pathways	epigenetic regulation

Pathway Diagram

graph TD
    MUC1[MUC1]
    MUC1 -->|upregulates| NF_KB[NF-KB]
    MUC1 -->|participates in| oxidative_stress_response[oxidative stress response]
    MUC1 -->|regulates| NEAT1[NEAT1]
    MUC1 -->|activates| MYC[MYC]
    MUC1 -->|activates| NONO[NONO]
    MUC1 -->|activates| SFPQ[SFPQ]
    MUC1 -->|activates| cancer[cancer]
    MUC1 -->|regulates| MUC16[MUC16]
    MUC1 -->|regulates| SMARCA4[SMARCA4]
    FUS[FUS] -->|activates| MUC1
    APC[APC] -->|regulates| MUC1
    AXIN1[AXIN1] -->|regulates| MUC1
    AXIN2[AXIN2] -->|regulates| MUC1
    BRG1[BRG1] -->|regulates| MUC1
    CBP[CBP] -->|regulates| MUC1
    CDH5[CDH5] -->|regulates| MUC1
    CREBBP[CREBBP] -->|regulates| MUC1
    CTNNB1[CTNNB1] -->|regulates| MUC1
    EP300[EP300] -->|regulates| MUC1

Outgoing (22)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:MUC1	data_in	dataset_row	0.00
NF-KB	upregulates	pathway	0.80
oxidative stress response	participates_in	pathway	0.70
MYC	activates	gene	0.60
NEAT1	activates	gene	0.60
NONO	activates	gene	0.60
SFPQ	activates	gene	0.60
cancer	associated_with	disease	0.60
cancer	activates	disease	0.60
NF-kB signaling	participates_in	pathway	0.60
ROS	causes	gene	0.60
TJP1	biomarker_for	gene	0.60
NEAT1	regulates	gene	0.60
NEAT1	associated_with	gene	0.60
ROS	inhibits	gene	0.60
ROS	interacts_with	gene	0.60
MUC16	regulates	gene	0.60
SMARCA4	regulates	gene	0.60
OCLN	biomarker_for	gene	0.60
RNA	activates	gene	0.60
epigenetic regulation	participates_in	pathway	0.60
stem cells	expressed_in	cell_type	0.55

Incoming (17)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:MUC1	data_in	dataset_row	0.00
AXIN1	regulates	gene	0.60
AXIN2	regulates	gene	0.60
BRG1	regulates	gene	0.60
CBP	regulates	gene	0.60
APC	regulates	gene	0.60
CREBBP	regulates	gene	0.60
CTNNB1	regulates	gene	0.60
EP300	regulates	gene	0.60
FOXM1	regulates	gene	0.60
CDH5	regulates	gene	0.60
FUS	activates	gene	0.60
CDH1	regulates	gene	0.60
LRP1	biomarker_for	gene	0.60
HIF	activates	gene	0.60
AQP5	biomarker_for	gene	0.60
INSR	biomarker_for	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Astrocytic Surface Glycoprotein Modulation	0.000	-	4R-tau strain-specific spreading pattern

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MUC1 in their description or question text

No additional research found