DLK

Understanding Entity Pages

This page aggregates everything SciDEX knows about DLK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

DLK (MAP3K12) - key kinase in axonal injury signaling, JNK pathway activation, and Wallerian degeneration

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graph TD
    DLK["<b>DLK</b>"]
    Ms{"Ms"}
    DLK -->|"activates"| Ms
    Dementia{"Dementia"}
    DLK -->|"inhibits"| Dementia
    Alzheimer{"Alzheimer"}
    DLK -->|"regulates"| Alzheimer
    Neurodegeneration{"Neurodegeneration"}
    DLK -->|"inhibits"| Neurodegeneration
    Als{"Als"}
    DLK -->|"inhibits"| Als
    DLK -->|"inhibits"| Ms
    Apoptosis(["Apoptosis"])
    DLK -->|"activates"| Apoptosis
    Mapk(["Mapk"])
    DLK -->|"activates"| Mapk
    PUMA["PUMA"]
    DLK -->|"activates"| PUMA
    Autophagy(["Autophagy"])
    DLK -->|"inhibits"| Autophagy
    Blood_Brain_Barrier(["Blood-Brain Barrier"])
    DLK -->|"inhibits"| Blood_Brain_Barrier
    Mitophagy(["Mitophagy"])
    DLK -->|"inhibits"| Mitophagy
    BAX["BAX"]
    BAX -->|"activates"| DLK
    PUMA -->|"activates"| DLK
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"inhibits"| DLK
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"inhibits"| DLK
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"regulates"| DLK
    ULK1["ULK1"]
    ULK1 -->|"inhibits"| DLK
    TAU_TANGLES["TAU TANGLES"]
    TAU_TANGLES -->|"inhibits"| DLK
    TAU_PATHOLOGY["TAU PATHOLOGY"]
    TAU_PATHOLOGY -->|"inhibits"| DLK
    TAU["TAU"]
    TAU -->|"inhibits"| DLK
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"inhibits"| DLK
    NAD["NAD"]
    NAD -->|"activates"| DLK
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"activates"| DLK
    style DLK fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0