concept

CHOLINERGIC SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHOLINERGIC SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections

2Hypotheses

3Analyses

7Outgoing

31Incoming

4Experiments

3Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	CHOLINERGIC SIGNALING

Pathway Diagram

graph TD
    CHOLINERGIC_SIGNALING["CHOLINERGIC SIGNALING"]
    CHOLINERGIC_SIGNALING -->|"regulates"| Microglia["Microglia"]
    CHOLINERGIC_SIGNALING -->|"regulates"| Astrocyte["Astrocyte"]
    CHOLINERGIC_SIGNALING -->|"regulates"| Neuron["Neuron"]
    CHOLINERGIC_SIGNALING -->|"regulates"| Macrophage["Macrophage"]
    CHOLINERGIC_SIGNALING -->|"interacts"| NEURODEGENERATION["NEURODEGENERATION"]
    CHOLINERGIC_SIGNALING -->|"interacts"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    CHOLINERGIC_SIGNALING -->|"interacts"| INFLAMMATION["INFLAMMATION"]
    APOPTOSIS["APOPTOSIS"] -->|"target for"| CHOLINERGIC_SIGNALING
    ALZHEIMER["ALZHEIMER"] -->|"implicated in"| CHOLINERGIC_SIGNALING
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"target for"| CHOLINERGIC_SIGNALING
    INFLAMMATION -->|"target for"| CHOLINERGIC_SIGNALING
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"implicated in"| CHOLINERGIC_SIGNALING
    Als["Als"] -->|"target for"| CHOLINERGIC_SIGNALING
    Inflammation["Inflammation"] -->|"target for"| CHOLINERGIC_SIGNALING
    Alzheimer["Alzheimer"] -->|"implicated in"| CHOLINERGIC_SIGNALING

Outgoing (7)

Target	Relation	Type	Str
Microglia	regulates	cell_type	0.50
Astrocyte	regulates	cell_type	0.50
Neuron	regulates	cell_type	0.50
Macrophage	regulates	cell_type	0.50
NEURODEGENERATION	interacts_with	process	0.35
NEUROINFLAMMATION	interacts_with	process	0.35
INFLAMMATION	interacts_with	process	0.35

Incoming (31)

Source	Relation	Type	Str
stellate neurons	modulates	cell_type	0.70
CHRNA7	regulates	gene	0.70
CHRM1	regulates	gene	0.70
ALZHEIMER	implicated_in	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	implicated_in	gene	0.60
Als	therapeutic_target	disease	0.60
Inflammation	therapeutic_target	disease	0.60
Alzheimer	implicated_in	disease	0.60
APOPTOSIS	therapeutic_target	gene	0.60
neurodegeneration	involves	disease	0.60
neuroinflammation	involves	disease	0.60
ASTROCYTES	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
AGING	activates	gene	0.60
aging	involves	disease	0.60
CLOCK	activates	gene	0.60
BAD	regulates	gene	0.60
App	activates	protein	0.55
Fus	regulates	protein	0.55
App	regulates	protein	0.55
Senescence	activates	disease	0.55
Aging	activates	disease	0.55
Neurodegeneration	activates	disease	0.55
Neuroinflammation	activates	disease	0.55
Ischemia	regulates	disease	0.55
Neuroinflammation	regulates	disease	0.55
Hypertension	regulates	disease	0.55
acetylcholine-producing bacteria	modulates	process	0.50
AGING	interacts_with	process	0.35

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Direct Toxicity Hypothesis: β-Amyloid Directly Impairs Choli	0.769	-	Do β-amyloid plaques and neurofibrillary
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A	0.669	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (3)

Scientific analyses that reference this entity

Do β-amyloid plaques and neurofibrillary tangles cause or result from cholinergi

neurodegeneration | 2026-04-12 | 3 hypotheses Top: 0.887

Do stellate neurons express unique α7 nicotinic receptor subtypes that could ena

neurodegeneration | 2026-04-10 | 0 hypotheses

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.924

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Electroacupuncture ST37 treatment for DSS-induced colitis in mice	validation	colitis	0.950	mice	proposed	N/A
HFD-induced cognitive dysfunction and neuroinflammation in mice	validation	diet-induced cognitive dysfunc	0.900	adult Swiss male mice	proposed	N/A
α7nAChR agonist treatment rescues HFD-induced memory deficits	validation	diet-induced cognitive dysfunc	0.850	HFD-fed adult Swiss male mice	proposed	N/A
α7nAChR knockout mice show enhanced HFD sensitivity	validation	diet-induced cognitive dysfunc	0.800	Chrna7 knockout mice	proposed	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Astrocytic α7-nicotinic acetylcholine receptors mediate pain information process [PMID:41453579]	Teng T, Yang S, Li J, Wang H, Wu F, He Y	Neurobiology of disease	2026
Signal-Level Determinants of Cognitive Decline With PPIs versus H2RAs: Transport [PMID:41663888]	Saihati HAA, Ahmed BY, Mosaad RM, El-Gar	Molecular nutrition & food res	2026
Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Ce [PMID:41928597]	Gholizadeh F, Hajiaghayi M, Rahbari N, C	Eur J Immunol	2026
Alpha 7 nicotinic acetylcholine receptor contributes to long-term cognitive reco [PMID:41270982]	Nguyen DT, Mendoza K, Hall C, Tan C, Cha	Experimental neurology	2026
Putative α7-selective ligands interact with α9-containing nicotinic acetylcholin [PMID:41890755]	Mobasher M, Hone AJ, Pilzecker M, Bozic	Frontiers in immunology	2026
Short-term exposure to a high-fat diet leads to neuroinflammation and impairs me [PMID:41565126]	Costa SO, Silva IM, Chaves WF, Esteves A	The Journal of nutritional bio	2026
Acetylcholine enhances HIF-1α signaling in pancreatic cancer cells under hypoxia [PMID:41608625]	Cho Y, Kim HG, Kang JH, Oh ET, Park HJ	International journal of biolo	2026
Central-peripheral neuroimmune dynamics in psychological stress and depression: [PMID:40610703]	Feng X, Jia M, Cai M, Zhu T, Hashimoto K	Molecular psychiatry	2025
The ATP-mediated cytokine release by macrophages is down-modulated by unconventi [PMID:41221292]	Wolf PMK, Hanke D, Singh VK, Keller HL,	Frontiers in immunology	2025
Vagus nerve stimulation as a promising neuroprotection for ischemic stroke via α [PMID:38504011]	Xia XM, Duan Y, Wang YP, Han RX, Dong YF	Acta Pharmacol Sin	2024
Splenic nerve denervation attenuates depression-like behaviors in Chrna7 knock-o [PMID:38944290]	["Yang Y", "Eguchi A", "Mori C", "Hashim	Journal of affective disorders	2024
Vagus nerve stimulation as a promising neuroprotection for ischemic stroke via α [PMID:38504011]	Xia XM, Duan Y, Wang YP, Han RX, Dong YF	Acta pharmacologica Sinica	2024
α7nAChR activation in AT2 cells promotes alveolar regeneration through WNT7B sig [PMID:37410546]	Unknown	JCI Insight	2023
A role of gut-microbiota-brain axis via subdiaphragmatic vagus nerve in depressi [PMID:36191806]	["Yang Y", "Eguchi A", "Wan X", "Chang L	Progress in neuro-psychopharma	2023
Unilateral Cervical Vagotomy Modulates Immune Cell Profiles and the Response to [PMID:36077246]	Newell-Rogers MK, Duong A, Nazarali R, T	International journal of molec	2022
Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal car [PMID:33547425]	Lieberwirth JK, Joset P, Heinze A, Hents	European journal of human gene	2021
Vagus Nerve Stimulation and the Cardiovascular System. [PMID:31109966]	Capilupi MJ, Kerath SM, Becker LB	Cold Spring Harbor perspective	2020
Environmental Regulation, Technological Innovation, and Export Competitiveness: [PMID:32102174]	Liu J, Xie J	International journal of envir	2020
Microglial memory of early life stress and inflammation: Susceptibility to neuro [PMID:31703966]	Desplats P, Gutierrez AM, Antonelli MC,	Neuroscience and biobehavioral	2020
Predicting Subjective Recovery from Lower Limb Surgery Using Consumer Wearables. [PMID:33442582]	Karas M, Marinsek N, Goldhahn J, Foschin	Digital biomarkers	2020

Debates (3)

Multi-agent debates referencing this entity

The debate proposed α7-containing heteromers (α7β2) might be enriched in stellat

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

The abstract explicitly questions whether AD's hallmark pathologies induce choli

closed · Rounds: 4 · Score: 0.79 · 2026-04-12

What are the mechanisms underlying what are the mechanisms by which gut microbio

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning CHOLINERGIC SIGNALING in their description or question text

No additional research found